Cov kws tshawb fawb tau tsim thawj zaug tsim cov tshuaj hydrogel uas ua ntej koom nrog cov ntaub so ntswg tshwj xeeb bioactive molecules ntawm cov kab sib txuas tshiab. Cov hydrogel tau piav qhia muaj peev xwm siv tau hauv cov ntaub so ntswg engineering
Ntaub so ntswg engineering yog kev txhim kho cov ntaub so ntswg thiab lub cev hloov pauv - peb-seem cellular tsim - muaj cov khoom zoo ib yam li cov ntaub so ntswg. Hlaws tshuab Lub hom phiaj ntawm kev kho, khaws cia lossis txhim kho cov ntaub so ntswg ua haujlwm los ntawm kev siv cov khoom siv lom neeg lom zem. Synthetic hydrogel Polymers tau raug qhuas tias yog cov neeg sib tw tau zoo los muab cov khoom siv kho tshuab zoo li no vim lawv qhov tshwj xeeb muaj pes tsawg leeg thiab cov qauv zoo sib xws nrog ntuj extracellular matrix. Hydrogels ua raws li cov ntaub so ntswg ib puag ncig thiab cov crosslinkers hauv hydrogels pab cov khoom siv los tswj nws cov qauv txawm tias nws tau nqus dej ntau. Txawm li cas los xij, tam sim no muaj hydrogels muaj kev lom neeg tsis muaj zog thiab yog li tsis tuaj yeem ua ib leeg los tsav kev ua haujlwm lom neeg tsim nyog. Lawv xav tau ntxiv ntawm biomolecules sib xws (piv txwv li kev loj hlob, cov nplaum nplaum) ua rau lawv yog ib feem tseem ceeb ntawm hydrogels.
Hauv kev tshawb fawb luam tawm rau lub Rau Hli 11 hauv Kev Txhawb Kev Tshawb Fawb, cov kws tshawb fawb tau tsim ib qho tshiab modular injectable hydrogel uas siv lub crosslinker hu ua PdBT - biodegradable compound - rau crosslinking ntawm hydrogel polymer los tsim o, bioactive hydrogel. PdBT suav nrog bioactive molecules los ntawm kev khi lawv hauv cov tshuaj sib txuas hauv cov hydrogel. Cov biomolecules tshwj xeeb tuaj yeem sib xyaw nrog PdBT ntawm chav sov thiab los ntawm kev ua kom bioactive molecules dhau los ua ib feem ntawm hydrogel. Xws li cov txheej txheem, tsim thawj zaug, muaj peev xwm khi rau cov ntaub so ntswg tshwj xeeb biomolecules ntawm chav tsev kub kom ua haujlwm tsis tas yuav tsum tau txhaj tshuaj thib ob lossis kab ke tom qab.
Cov biomolecules ntxiv tseem nyob ruaj khov rau hydrogel thiab tuaj yeem nthuav tawm ncaj qha rau cov ntaub so ntswg. Qhov no tiv thaiv kev sib kis mus rau thaj tsam sab nraud ntawm lub hom phiaj kom tsis txhob muaj qhov tshwm sim tsis zoo xws li inactivation lossis redundant cov ntaub so ntswg loj hlob. Cov kev sim tau ua rau cov pob txha thiab pob txha siv cov PdBT monomers tshwj xeeb los ntawm kev ntxiv kev ua haujlwm los ntawm kev sib koom ua ke ntawm pob txha mos hydrophobic N-cadherin peptide thiab hydrophilic pob txha morphogenetic protein peptide, thiab pob txha-derived glycosaminoglycan, chondroitin sulfate. Qhov sib xyaw hydrogel no tuaj yeem raug txhaj ncaj qha rau hauv cov ntaub so ntswg. Biomolecules incorporated nyob rau hauv hydrogel tuaj nyob rau hauv kev sib cuag nrog lub cev mesenchymal qia hlwb ntawm tus tswv tsev ntaub so ntswg thiab "lure" lawv kom lawv tau ntxiv rau lub hom phiaj cheeb tsam rau 'noob' los yog pib tshiab kev loj hlob. Thaum cov ntaub so ntswg tshiab loj tuaj, hydrogel degrades thiab ploj mus.
Cov hydrogel tshiab tau piav qhia hauv txoj kev tshawb fawb tam sim no tuaj yeem npaj tau ntawm chav tsev kub rau kev siv tam sim ntawd thiab tuaj yeem hloov kho raws li cov ntaub so ntswg sib txawv. Cov txheej txheem kev npaj ncaj qha tiv thaiv thermal degradation ntawm biomolecules uas tau teeb meem nrog cov hydrogels dhau los vim qhov no cuam tshuam rau lawv cov kev ua haujlwm lom neeg. Bioactive hydrogels tuaj yeem pab tsim cov pob txha, pob txha, tawv nqaij thiab lwm yam ntaub so ntswg. Cov txheej txheem tshiab no uas siv cov tshuaj bioactive hydrogel uas muaj cov khoom zoo muaj peev xwm siv tau rau hauv cov ntaub so ntswg engineering.
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{Koj tuaj yeem nyeem cov ntawv tshawb fawb thawj zaug los ntawm nyem rau ntawm DOI qhov txuas tau muab hauv qab no hauv cov npe ntawm cov khoom raug suav nrog}
Qhov (s)
Guo JL et al. 2019. Modular, cov ntaub so ntswg tshwj xeeb, thiab biodegradable hydrogel cross-linkers rau cov ntaub so ntswg engineering. Science Advance. 5 (6). https://doi.org/10.1126/sciadv.aaw7396
