Cov kws tshawb fawb tau tsim 3D bioprinting platform uas sib sau ua haujlwm tib neeg cov ntaub so ntswg neural. Cov hlwb progenitor nyob rau hauv cov ntaub so ntswg loj hlob mus rau hauv neural circuits thiab ua kom muaj kev sib raug zoo nrog lwm cov neurons yog li mimicking ntuj. lub hlwb cov ntaub so ntswg. Qhov no yog ib qho kev nce qib tseem ceeb hauv cov ntaub so ntswg engineering thiab hauv 3D bioprinting thev naus laus zis. Xws li cov ntaub so ntswg bioprinted neural tuaj yeem siv los ua qauv tib neeg Cov kab mob (xws li Alzheimer's, Parkinson's thiab lwm yam) tshwm sim vim kev puas tsuaj ntawm neural networks. Txhua qhov kev tshawb nrhiav kab mob ntawm lub paj hlwb yuav tsum nkag siab tias yuav ua li cas tib neeg neural networks ua haujlwm.
3D bioprinting yog cov txheej txheem ntxiv uas tsim nyog los yog khoom siv biomaterial (bioink) sib xyaw nrog cov hlwb nyob thiab luam tawm, txheej-los-txheej, hauv cov ntaub so ntswg-zoo li-peb-dimensional qauv. Cov hlwb loj hlob hauv bioink thiab cov qauv tsim los ua cov ntaub so ntswg los yog lub cev. Cov tshuab no tau pom cov ntawv thov hauv tsim dua tshiab tshuaj rau bioprinting ntawm cov hlwb, cov ntaub so ntswg thiab kabmob thiab hauv kev tshawb fawb ua qauv los kawm tib neeg lub cev nyob rau hauv vitro, tshwj xeeb tib neeg paj hlwb.
Kev kawm ntawm tib neeg paj hlwb ntsib kev txwv vim tsis muaj cov qauv thawj. Cov qauv tsiaj muaj txiaj ntsig tab sis raug kev txom nyem los ntawm hom tshwj xeeb sib txawv li no qhov tseem ceeb ntawm nyob rau hauv vitro qauv ntawm cov tib neeg paj hlwb los soj ntsuam li cas cov tib neeg Neural networks ua haujlwm los nrhiav kev kho mob rau cov kab mob vim yog kev puas tsuaj ntawm neural networks.
Tib neeg Cov ntaub so ntswg neural tau 3D luam tawm yav dhau los siv cov qia hlwb tab sis cov tsis muaj neural network tsim. Cov ntaub ntawv luam tawm tsis tau pom tias muaj kev sib txuas ntawm cov hlwb vim ntau yam. Cov kev tsis txaus no tau kov yeej tam sim no.
Hauv txoj kev tshawb fawb tsis ntev los no, soj ntsuam ntawm xaiv fibrin hydrogel (suav nrog fibrinogen thiab thrombin) raws li cov bioink yooj yim thiab npaj los luam ib txheej txheej uas cov hlwb progenitor tuaj yeem loj hlob thiab tsim cov synapses nyob rau hauv thiab hla cov khaubncaws sab nraud povtseg, tab sis lawv hloov txoj kev txheej txheej thaum luam ntawv. Es tsis txhob ntawm txoj kev niaj hnub ntawm stacking txheej vertically, lawv xaiv los luam cov khaubncaws sab nraud povtseg ntawm lwm kab rov tav. Thaj, qhov no ua qhov txawv. Lawv 3D bioprinting platform tau pom los sib sau ua haujlwm tib neeg cov ntaub so ntswg neural. Kev txhim kho dua lwm cov platforms uas twb muaj lawm, lub tib neeg cov ntaub so ntswg neural luam tawm los ntawm lub platform no tsim neural tes hauj lwm thiab kev sib txuas nrog lwm cov neurons thiab glial hlwb nyob rau hauv thiab nruab nrab ntawm cov khaubncaws sab nraud povtseg. Qhov no yog thawj rooj plaub thiab yog ib kauj ruam tseem ceeb rau pem hauv ntej hauv neural ntaub so ntswg engineering. Laboratory synthesis ntawm cov paj hlwb uas ua rau lub hlwb ua haujlwm zoo siab heev. Qhov kev vam meej no yeej yuav pab tau cov kws tshawb fawb hauv kev ua qauv tib neeg kab mob ntawm lub paj hlwb tshwm sim los ntawm impaired neural network kom nkag siab zoo dua rau kev nrhiav kev kho mob.
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References:
- Cadena M., UA thiab al 2020. 3D Bioprinting ntawm Neural Tissues. Advanced Healthcare Materials Volume 10, Issue 15 2001600. DOI: https://doi.org/10.1002/adhm.202001600
- Yan Y., thiab al 2024. 3D bioprinting ntawm tib neeg neural cov ntaub so ntswg nrog functional connectivity. Cell Stem Cell Technology| Volume 31, Issue 2, P260-274.E7, Lub Ob Hlis 01, 2024. DOI: https://doi.org/10.1016/j.stem.2023.12.009
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