Tshav Pharma tau nthuav tawm cov ntaub ntawv ntawm ODOMZO® (tshuaj rau kev kho mob qog noj ntshav ntawm daim tawv nqaij) thiab LEVULAN® KERASTICK® + BLU-U®, (rau kev kho cov kab mob precancerous) txhawb kev nyab xeeb thiab kev ua tau zoo.
ODOMZO®
ODOMZO® (Sonidegib) tau pom zoo los ntawm FDA thaum Lub Xya Hli 2015. Qhov no tau txais los ntawm Tshav Pharma los ntawm Novartis thaum Lub Kaum Ob Hlis 2016 rau $ 175 lab them nyiaj ua ntej nrog rau kev them nyiaj tseem ceeb.
Nws yog ib qho tshuaj tshuaj noj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj los kho lub zos basal cell carcinoma, uas tau resurfaced tom qab kev phais los yog hluav taws xob, los yog tsis tau kho nrog phais los yog hluav taws xob. Qhov no yog ib qho inhibitor ntawm Hedgehog signaling txoj kev. Txoj hauv kev Hedgehog (Hh) yog nquag siv thaum lub sij hawm embryogenic txoj kev loj hlob thiab tsim nyog rau kev sib txawv ntawm tes, cov ntaub so ntswg polarity, thiab qia cell tu. Txoj kev no yog ntsiag to nyob rau hauv cov neeg laus cov ntaub so ntswg nyob rau hauv ib txwm physiological tej yam kev mob, txawm li cas los, aberrant Hh signaling activation tau implicated nyob rau hauv txoj kev loj hlob thiab nce qib ntawm tej yam kev mob. cancer, suav nrog basal cell carcinoma (BCC), medulloblastoma, thiab plab hnyuv Cancer. Basal cell carcinoma thiab squamous cell carcinoma yog feem ntau hom nonmelanoma cov tawv nqaij ua tawv nqaij thiab cuam tshuam ntau dua peb lab tus neeg Asmeskas txhua xyoo.
BOLT soj ntsuam kev sim rau Odomzo, ob-dig muag, randomized, tswj, 42-hli txoj kev tshawb fawb soj ntsuam ODOMZO 200 mg ib hnub twg hauv 230 cov neeg mob uas muaj cov kab mob hauv zos basal cell carcinoma (laBCC) thiab metastatic basal cell carcinoma (mBCC). 2-xyoo tag nrho cov ciaj sia nyob tau pom tias yog 93.2% (laBCC) thiab 69.3% (mBCC). Cov tshuaj no muaj kev nyab xeeb.
LEVULAN® KERASTICK® + BLU-U®
Qhov no tsuas yog photodynamic kho rau precancerous daim tawv nqaij Cov kab mob tau pom zoo los ntawm FDA (hauv Lub Xya Hli 1999) rau kev siv rau sab sauv sab sauv los kho 'tsawg kawg rau nruab nrab' tuab actinic keratoses ntawm lub ntsej muag, tawv taub hau lossis sab qaum. Cov no yog precancerous Cov tawv nqaij loj hlob uas, yog tias tsis kho, yuav tig mus ua squamous cell carcinoma. Thaum tsuas yog li ntawm 10 feem pua ntawm cov actinic keratoses ua ua cancerFeem ntau ntawm cov kab mob squamous cell carcinoma pib ua actinic keratosis.
LEVULAN KERASTICK 20% tshuaj pleev ib ce, ntxiv rau xiav lub teeb pom kev zoo yog siv los kho qhov mob. Tom qab LEVULAN KERASTICK cov tshuaj pleev ib ce tau siv, qhov chaw kho mob tau dhau los ua photosensitive thiab cov neeg mob yuav tsum tsis txhob raug cov chaw kho mob photosensitive rau tshav ntuj los yog ci ntsa iab sab hauv tsev (piv txwv li, teeb tshuaj ntsuam, teeb chav ua haujlwm, lub txaj tanning, lossis teeb nyob ze) rau 40 teev.
Hauv kev sim tshuaj ntsuam xyuas, muaj kev tshem tawm ntau dua ntawm qhov txhab (80.6%) hauv cov neeg mob kho nrog qhov kev kho no piv rau cov placebo (45.5%). Tsis tas li ntawd, muaj kev tshem tawm ntau dua ntawm thaj chaw muaj kab mob ntau dua hauv 80% ntawm cov neeg mob noj cov tshuaj no piv rau 40% nrog cov placebo. Txoj kev kho tau zoo zam yam tsis muaj kev tshaj tawm txog kev kho mob tseem ceeb.
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