Ib qho tshuaj tiv thaiv tshiab, R21 / Matrix-M tau pom zoo los ntawm WHO rau kev tiv thaiv kab mob malaria hauv cov menyuam yaus.
Ua ntej xyoo 2021, WHO tau pom zoo RTS, S/AS01 tshuaj tiv thaiv kab mob malaria rau kev tiv thaiv ntawm malaria hauv cov menyuam yaus. Qhov no yog thawj zaug malaria tshuaj tiv thaiv kom pom zoo.
R21/Matrix-M yog hom tshuaj tiv thaiv kab mob malaria thib ob uas tau pom zoo los ntawm WHO rau kev tiv thaiv tus kabmob malaria ntawm cov menyuam yaus.
Raws li kev txwv tsis pub siv tshuaj tiv thaiv RTS, S / AS01, kev pom zoo thib ob malaria tshuaj tiv thaiv R21/Matrix-M yuav tsum tau sau cov khoom sib txawv kom tau raws li qhov xav tau siab.
Kev pom zoo ntawm cov tshuaj tiv thaiv R21/Matrix-M yog ua raws li cov txiaj ntsig zoo ntawm theem III kev sim tshuaj ntsuam xyuas uas muaj 4800 tus menyuam yaus hla tsib qhov chaw hauv plaub lub tebchaws African. Cov tshuaj tiv thaiv tau muaj kev tiv thaiv zoo rau kev nyab xeeb thiab muaj kev ua haujlwm siab tiv thaiv kev kho mob malaria.
Cov tshuaj tiv thaiv tshiab no yog cov tshuaj tiv thaiv tus nqi qis thiab xav tias yuav muaj kev cuam tshuam rau pej xeem kev noj qab haus huv ntau ntawm cov kab mob hauv sub-Saharan Africa.
Ob qho tshuaj tiv thaiv R21 / Matrix-M thiab RTS, S / AS01 yog cov tshuaj tiv thaiv kab mob zoo ib yam li cov tshuaj tiv thaiv kab mob raws li circumsporozoite protein (CSP) antigen li no. Ob lub hom phiaj plasmodium sporozoite. Txawm li cas los xij, R21 muaj ib qho CSP-hepatitis B nto antigen (HBsAg) fusion protein. Qhov no ua rau cov tshuaj tiv thaiv CSP ntau dua thiab qis dua los tiv thaiv HBsAg cov tshuaj tiv thaiv kab mob uas ua rau nws yog cov tshuaj tiv thaiv tom ntej RTS, S-zoo li tshuaj tiv thaiv.
R21/Matrix-M malaria tshuaj tiv thaiv yog tsim los ntawm University of Oxford. Nws yog tsim los ntawm Serum Institute of India (SII) uas twb muaj peev xwm tsim tau rau 100 lab koob tshuaj ib xyoos. SII yuav muab lub peev xwm ntau lawm ob xyoos tom ntej kom tau raws li qhov xav tau.
WHO cov lus pom zoo ua rau txoj hauv kev rau kev yuav khoom thiab yuav cov tshuaj tiv thaiv rau kev txhaj tshuaj tiv thaiv menyuam yaus hauv thaj chaw muaj xwm txheej.
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Qhov chaw:
- WHO Xov Xwm Tshaj Tawm - WHO pom zoo tshuaj tiv thaiv R21 / Matrix-M rau kev tiv thaiv kab mob npaws hauv cov lus qhia tshiab ntawm kev txhaj tshuaj. Tshaj tawm rau 2 Lub Kaum Hli 2023. Muaj nyob ntawm https://www.who.int/news/item/02-10-2023-who-recommends-r21-matrix-m-vaccine-for-malaria-prevention-in-updated-advice-on-immunization Tau txais los ntawm Lub Ob Hlis 3, 2023.
- Datoo, MS, thiab al 2023. Ib Theem III Randomized Controlled Trial ntsuam xyuas cov tshuaj tiv thaiv kab mob malaria Candidate R21/Matrix-M™ hauv African Menyuam yaus. Preprint ntawm SSRN. DOI: http://doi.org/10.2139/ssrn.4584076
- Laurens MB, 2020. RTS,S/AS01 vaccine (Mosquirix™): ib qho kev piav qhia. Hum Vaccin Immunother. 2020; 16(3): 480–489.Published online 2019 Kaum Hli 22. DOI: https://doi.org/10.1080/21645515.2019.1669415
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