RNA thev naus laus zis tau ua pov thawj tias nws muaj nqis tsis ntev los no hauv kev tsim cov tshuaj tiv thaiv mRNA BNT162b2 (ntawm Pfizer/BioNTech) thiab mRNA-1273 (ntawm Moderna) tiv thaiv COVID-19. Raws li kev degrading lub coding RNA nyob rau hauv cov qauv tsiaj, Fabkis cov kws tshawb fawb tau tshaj tawm lub tswv yim muaj zog thiab pov thawj ntawm lub tswv yim rau kev kho mob rau Charcot-Marie-Tooth. kab mob, feem ntau cov kab mob hauv lub paj hlwb uas ua rau tuag tes tuag taw ntawm ob txhais ceg thiab tes.
Xyoo 1990, cov kws tshawb fawb tau pom thawj zaug tias kev txhaj tshuaj ncaj qha ntawm mRNA rau hauv nas nqaij coj mus rau kev qhia ntawm encoded protein nyob rau hauv cov leeg nqaij. Qhov no tau qhib qhov muaj peev xwm ntawm kev loj hlob ntawm gene-based tshuaj tiv thaiv thiab kho mob.
Qhov xwm txheej tsis tau nthuav tawm los ntawm COVID-19 kis thoob qhov txhia chaw, ua rau muaj kev vam meej thiab kev tso cai siv thaum muaj xwm txheej ceev (EUA) ntawm mRNA-based tshuaj tiv thaiv BNT162b2 (ntawm Pfizer/BioNTech) thiab mRNA-1273 (ntawm Niaj hnub) tiv thaiv COVID-19. Ob tug no tshuaj tiv thaiv raws li RNA thev naus laus zis tau ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv tib neeg los ntawm cov tsos mob hnyav ntawm COVID-19.
Kev vam meej ntawm RNA thev naus laus zis raws li COVID-19 tshuaj tiv thaiv tau suav hais tias yog lub hauv paus tseem ceeb hauv kev tshawb fawb thiab tshuaj raws li nws tau ua pov thawj tsim nyog ntawm lub peev xwm kho mob zoo tshaj plaws uas cov zej zog kev tshawb fawb thiab kev lag luam tshuaj tau nrhiav tau yuav luag peb xyoo lawm. Nws tau muab qhov kev xav tau ntau rau kev tshawb nrhiav RNA thev naus laus zis raws li kev kho mob.
Kab mob Charcot-Marie Tooth yog hom kab mob uas tshwm sim ntau tshaj plaws kab mob. Cov hlab ntsha peripheral cuam tshuam uas ua rau tuag tes tuag taw ntawm ob txhais ceg thiab tes. Tus kab mob no tshwm sim los ntawm overexpression ntawm ib tug tshwj xeeb protein hu ua PMP22. Tam sim no tsis muaj kev kho mob rau tus kab mob no.
Cov kws tshawb fawb ntawm CNRS, INSERM, AP-HP thiab Paris-Saclay thiab Paris cov tsev kawm qib siab hauv Fabkis tsis ntev los no tau tshaj tawm txog kev txhim kho kev kho mob raws li kev degrading thiab txo cov coding RNA rau PMP22 protein. Rau qhov no, lawv siv lwm yam siRNA (me me cuam tshuam RNA) molecule uas cuam tshuam nrog RNA coding rau PMP22 protein.
Cov kws tshawb fawb tau pom tias kev txhaj tshuaj ntawm siRNA (me me cuam tshuam RNA) hauv cov nas qauv ntawm tus kab mob txo qis PMP22 protein kom zoo thiab rov ua haujlwm thiab lub zog ntawm cov leeg. Cov kev tshawb fawb histological tau qhia txog kev tsim kho tshiab thiab kev ua haujlwm ntawm myelin sheaths. Cov txiaj ntsig zoo tau kav ntev li peb lub lis piam, thiab kev txhaj tshuaj tshiab ntawm siRNA coj mus rau kev ua haujlwm puv ntoob.
Qhov no txoj kev tshawb no Nws yog ib qho tseem ceeb rau nws qhia ib lub tswv yim muaj zog rau kev kho mob ntawm hereditary peripheral neuropathies. Nws muab cov pov thawj ntawm lub tswvyim rau cov tshuaj precision tshiab raws li daim ntawv thov ntawm RNA thev naus laus zis los kho cov kab mob ntau dhau los ntawm kev siv cuam tshuam RNA.
Txawm li cas los xij, qhov kev kho mob tiag tiag ntawm tus neeg mob tseem yog txoj hauv kev ntev mus txog rau theem ua tiav ntawm cov kev sim tshuaj ntsuam xyuas muab kev nyab xeeb thiab kev ua tau zoo rau cov neeg tswj hwm.
***
Qhov chaw:
- Prasad U., 2020. COVID-19 mRNA Vaccine: Ib Qhov Tseem Ceeb hauv Kev Tshawb Fawb thiab Kev Hloov Pauv Hauv Tshuaj. Kev tshawb fawb European. Tshaj tawm rau lub Ob Hlis 29, 2020. Avaialble at https://www.scientificeuropean.co.uk/covid-19/covid-19-mrna-vaccine-a-milestone-in-science-and-a-game-changer-in-medicine/
- Kev Tshaj Tawm - Inserm Press Room - Charcot-Marie Tooth disease: 100% French RNA-based therapeutic innovation. Txuas: https://presse.inserm.fr/en/charcot-marie-tooth-disease-a-100-french-rna-based-therapeutic-innovation/42356/
- Boutary, S., Caiillaud, M., El Madani, M. et al. Squalenoyl siRNA PMP22 nanoparticles muaj txiaj ntsig zoo hauv kev kho nas qauv ntawm Charcot-Marie-Tooth kab mob hom 1 A. Commun Biol 4, 317 (2021). https://doi.org/10.1038/s42003-021-01839-2
***
 and mRNA-1273 (of Moderna)){kind=link}