Cov kws tshawb fawb tau pom txoj hauv kev tshiab hauv nas kom tau txais kev kho mob los ntawm qhov mob neuropathic mob ntev
Neuropathic mob nyob rau hauv tib neeg yog ib tug mob ntev txuam nrog hlab ntsha puas zoo li neuropathy. Qhov no yog qhov nyuaj heev los kho cov mob ntev mob uas feem ntau pom nyob rau hauv hlab ntsha kev raug mob, chemotherapy thiab ntshav qab zib. Qhov mob yog xa qhov ncauj koob tshuaj insulin rau cov neeg mob ntshav qab zib hom 1: Kev sim ua tau zoo hauv Pigsooting thiab khaus thiab / lossis ua rau muaj kev ntxhov siab lossis tsis hnov qab. Qhov mob feem ntau tuaj yeem ua rau muaj kev raug mob, phais, mob lossis kis kab mob thiab tuaj yeem tshwm sim tas li lossis tsis sib xws, hloov pauv thiab nws tuaj yeem maj mam zoo dua lossis phem dua hauv qee tus neeg mob.
Ua rau nyuaj-rau-kho mob neuropathic
Tib neeg lub paj hlwb yog tsim los ntawm ib tug complex sau ntawm hlab ntsha thiab mob siab rau cov hlwb hu ua neurons uas xa cov cim ntawm lub hlwb mus rau ntau qhov chaw ntawm lub cev. Leeg yog ua los ntawm cov paj hlwb hu ua axons. Neuropathic mob nyob rau hauv tib neeg yog tshwm sim los ntawm ib feem puas axons ntawm a hlab ntsha. Nyob rau hauv cov tsiaj thaum lub peripheral hlab ntsha tau crushed, nws tau puas lawm thiab puas axons ces tso cai rau kev loj hlob ntawm noj qab nyob zoo axons nyob rau hauv lub hlab ntsha. Qhov no tsis tshwm sim hauv tib neeg thiab yog vim li cas qhov mob neuropathic mob nyob rau hauv. Kev tswj qhov mob ntev yog qhov nyuaj heev thiab yuav tsum tau siv zog ntau los ua kom nws zoo li zam tau thaum tswj lub cev ua haujlwm. Tsuas yog ob peb tus neeg mob tau txais kev pab los ntawm qhov mob no nrog kev siv tshuaj ib leeg vim tias kev kuaj mob ntawm tus mob neuropathic yeej tsis poob rau ib qho laj thawj. Cov tshuaj tua kab mob, tshuaj kho mob thiab kho lub cev tau qhia tab sis feem ntau ntawm cov xwm txheej lawv tsis tuaj yeem rhuav tshem lub voj voog ntev. mob.
Nrhiav kev kho mob rau cov mob neuropathic
Txij li thaum nws tau tsim tias qhov laj thawj tseem ceeb rau mob neuropathic hauv tib neeg yog ib feem puas axons sab hauv hlab ntsha, nws yuav yog qhov tseem ceeb los tshawb nrhiav qhov tshwj xeeb no. Nyob rau hauv ib txoj kev tshawb fawb tshiab luam tawm nyob rau hauv cell, cov kws tshawb fawb tsom kom nkag siab txog lub luag haujlwm ntawm peb lub cev tiv thaiv kab mob hauv kev rhuav tshem peb cov kev puas tsuaj (ib nrab lossis lwm yam) hlab ntsha. Lawv saib ntawm lub cev tiv thaiv kab mob hu ua natural killer lossis NK uas tuaj yeem txiav axons los ntawm cov neurons hauv cov tais petri hauv chav kuaj. Cov NK hlwb no yog ib feem ntawm peb lub cev lub cev tiv thaiv kab mob los ntawm qhov uas peb lub cev tiv thaiv kab mob tiv thaiv peb ntawm cov kab mob thiab mob qog noj ntshav.Nws tau pom tias cov neurons disassociated tau nthuav tawm cov protein hu ua RAE1 uas ces caw NK hlwb los tsom rau cov neurons.Yog li, ib zaug neurons tau loj hlob. nrog rau NK hlwb ua haujlwm, cov hlwb no pib rhuav tshem cov hlab ntsha raug mob / ib feem puas los ntawm kev noj cov axons tab sis, tsis ua kom lawv lub cev puas tsuaj. Yog li ntawm no yog qhov muaj peev xwm loj hlob tshiab axons noj qab haus huv nyob rau hauv qhov chaw uas puas lawm.
Kev sim tam sim no tau ua nyob rau hauv cov nas nyob hauv thawj zaug ua rau muaj kev ua haujlwm ntawm NK hlwb thiab tom qab ntawd crushing nas lub paj hlwb ntawm ceg. Tsis pub dhau ib lub sij hawm luv luv, lub cev tiv thaiv kab mob ua rau cov nas ua rau txo qis rhiab heev hauv lawv cov paw cuam tshuam. Tom qab ib ntus, cov kws tshawb fawb tau sau tseg tias cuam tshuam cov neurons pib ua cov protein uas tom qab ntawd ua rau cov neurons muaj kev cuam tshuam los ntawm NK hlwb. NK hlwb tau teb tam sim ntawd los ntawm kev nkag mus rau cov hlab ntsha thiab tshem tawm cov axons puas. Thaum cov axons puas tau raug tshem tawm, cov neeg noj qab haus huv tau pib loj hlob hauv lawv qhov chaw. Thiab tom qab li ob lub lis piam, nas tau txais kev hnov qab hauv lawv cov paws cuam tshuam. Cov pab pawg tswj hwm ntawm cov nas uas tsis tau txais kev tiv thaiv kev tiv thaiv kom nce lawv cov NK hlwb kuj zoo li qub nyob rau lub sijhawm zoo sib xws. Tab sis qhov tseem ceeb tshaj plaws yog tias txij li cov pab pawg tswj hwm cov nas puas axons tsis raug tshem tawm, lawv txuas ntxiv txhawb nqa qhov mob hnyav rau yuav luag ib hlis tom qab raug mob.
Qhov kev sim tau ua tiav hauv tus qauv tsiaj thiab cov kws tshawb fawb tau ntseeg siab tias qhov xwm txheej zoo sib xws tuaj yeem pom hauv tib neeg thiab thaum tshwm sim ntawm qhov mob neuropathic. Cov hlab ntsha ib nrab puas hauv tib neeg txuas ntxiv xa cov teeb liab mus rau lub hlwb thiab ua rau mob ntev thiab mob siab rau ntev tom qab thawj zaug txhaj tshuaj ntawm qhov mob. Ib txoj hauv kev tuaj yeem tsim los ntawm tib neeg uas tuaj yeem hloov kho NK cell ua haujlwm thiab tshem tawm tag nrho cov axons ib nrab lossis puas lawm thiab tom qab ntawd tso cai rau kev noj qab haus huv axons loj hlob. Qhov no tuaj yeem kho qhov mob neuropathic zoo li pom los ntawm kev tshawb fawb tam sim no ntawm cov nas. Nkag siab txog lub luag haujlwm tseem ceeb ntawm NK hlwb hauv axonal degeneration yuav yog qhov tseem ceeb rau kev tsim kho mob rau cov mob neuropathic mob ntev hauv tib neeg.
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{Koj tuaj yeem nyeem cov ntawv tshawb fawb thawj zaug los ntawm nyem rau ntawm DOI qhov txuas tau muab hauv qab no hauv cov npe ntawm cov khoom raug suav nrog}
Qhov (s)
Davies AJ et al. 2019. Ntuj Killer Cells Degenerate Intact Sensory Afferents after Nerve Injury. cell. https://doi.org/10.1016/j.cell.2018.12.022
