Xyoo no Nobel Prize hauv Physiology lossis Medicine 2023 tau muab rau Katalin Karikó thiab Drew Weissman "rau lawv cov kev tshawb pom txog kev hloov pauv nucleoside uas ua rau muaj kev tsim cov tshuaj tiv thaiv mRNA zoo tiv thaiv COVID-19".
Ob leeg Katalin Karikó thiab Drew Weissman puav leej koom tes nrog University of Pennsylvania. Lawv cov kev pab txhawb rau kev siv cov thev naus laus zis mRNA rau kev txhaj tshuaj thiab kev kho mob tau hloov pauv qhov kev nkag siab txog seb mRNA cuam tshuam nrog lub cev tiv thaiv kab mob li cas thiab ua lub luag haujlwm tseem ceeb hauv kev tsim cov tshuaj tiv thaiv kab mob COVID-19 ntawm qhov nrawm tsis tau muaj dua los ua kom tau raws li qhov xwm txheej ceev.
Qhov xwm txheej tseem ceeb yog lawv qhov kev soj ntsuam uas cov hlwb dendritic lees paub hauv vitro transcribed mRNA raws li ib yam khoom txawv teb chaws thaum mRNA los ntawm cov kab mob mammalian tsis ua rau muaj kev tiv thaiv kab mob. Lawv tau tshawb xyuas yog tias qhov tsis muaj cov hauv paus hloov pauv hauv vitro transcribed RNA tuaj yeem raug ntaus nqi los ntawm qhov tsis xav tau cov tshuaj tiv thaiv kab mob thiab pom tias cov lus teb inflammatory raug tshem tawm thaum cov kev hloov pauv hauv paus suav nrog hauv mRNA. Qhov kev tshawb pom no tshem tawm qhov teeb meem tseem ceeb hauv kev siv mRNA thev naus laus zis rau kev tsim tshuaj tiv thaiv thiab kho mob thiab tau luam tawm xyoo 2005.
Kaum tsib xyoos tom qab, qhov xwm txheej tsis tau muaj dua los ntawm tus kab mob COVID-19 kis thoob plaws tau ua rau muaj kev sim tshuaj sai thiab EUA ntawm cov tshuaj tiv thaiv mRNA zoo tiv thaiv COVID-19. Tshuaj tiv thaiv mRNA tiv thaiv COVID-19 yog ib qho tseem ceeb hauv kev tshawb fawb thiab kev hloov pauv hauv kev kho mob.
Tam sim no, mRNA thev naus laus zis yog qhov pov thawj thev naus laus zis rau kev tsim cov tshuaj tiv thaiv thiab kev kho mob.
Tau qhov twg los:
NobelPrize.org. Xov Xwm Tshaj Tawm - Qhov Khoom Plig Nobel hauv Kev Ua Haujlwm lossis Tshuaj Kho Mob Xyoo 2023. Tshaj tawm rau hnub tim 2 Lub Kaum Hli 2023. Muaj nyob rau ntawm https://www.nobelprize.org/prizes/medicine/2023/press-release/
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