Cov tshuaj tua kab mob tam sim no siv nyob rau hauv kev kho mob, ntxiv rau neutralizing lub hom phiaj pathogens kuj ua rau cov kab mob noj qab haus huv hauv plab. Kev cuam tshuam hauv plab microbiome muaj tshuaj lom rau lub siab, lub raum thiab lwm yam kabmob. Qhov no yog ib qho teeb meem yuav tsum tau hais. Cov kws tshawb fawb tau tshawb pom lolamicin, tus neeg sib tw tshuaj tua kab mob uas tau pom tias muaj txiaj ntsig zoo tiv thaiv kab mob gram-tsis zoo yam tsis muaj kev cuam tshuam rau lub plab microbiome hauv kev tshawb fawb ua ntej. Qhov no yog pov thawj-ntawm-lub tswv yim hais tias cov tshuaj tua kab mob uas tua cov kab mob microbes thaum sparing cov kab mob zoo hauv plab tuaj yeem tsim rau cov kab mob gram-tsis zoo. Nws muaj kev cia siab rau kev daws teeb meem cuam tshuam nrog kev tsis sib haum xeeb ntawm cov kab mob gram-tsis zoo. Txawm li cas los xij, xyoo ntawm kev tshawb fawb ntxiv yog xav tau ua ntej nws mus txog theem ntawm kev siv tshuaj kho mob.
Feem ntau cov tshuaj tua kab mob tsuas yog tua cov kab mob gram-positive xwb lossis tua tau ob hom kab mob gram-positive thiab gram-negative. Qee cov tshuaj tua kab mob tshwj xeeb rau cov kab mob gram-negative (cov kab mob gram-negative muaj ob txheej tiv thaiv hauv lawv lub cell phab ntsa uas ua rau lawv nyuaj tua) kuj tua cov kab mob gram-negative zoo hauv plab. Cov teeb meem hauv plab hnyuv microbiome uas tsim los no pom tias muaj cov tshuaj lom / tsis zoo tshwj xeeb tshaj yog rau daim siab thiab lub raum. Yog li ntawd, qhov xav tau los tsim cov tshuaj tua kab mob uas tuaj yeem tua cov kab mob pathogenic thaum txuag cov zoo. Raws li tau tshaj tawm hauv daim ntawv tshawb fawb tsis ntev los no, cov kws tshawb fawb tau tsim ib qho tshuaj tua kab mob hu ua lolamicin uas tau pom tias tuaj yeem tua cov kab mob gram-negative thaum txuag cov zoo.
Lolamicin yog ib qho inhibitor ntawm Lol (localization ntawm lipoproteins) txoj hauv kev, lub lipoprotein-kev thauj mus los pom tshwj xeeb hauv cov kab mob gram-tsis zoo uas yog qhov sib txawv ntawm cov kab mob pathogenic thiab cov txiaj ntsig zoo.
Hauv kab lis kev cai ntawm tes, nws tsis muaj txiaj ntsig zoo rau cov kab mob gram-zoo. Thaum noj ntau dua, nws nruab nrab txog li 90% ntawm cov tshuaj tiv thaiv kab mob E. coli, K. pneumoniae thiab E. cloacae soj ntsuam cais tawm.
Kev tswj qhov ncauj ntawm lolamicin rau cov nas uas muaj tshuaj tiv thaiv kab mob septicemia lossis mob ntsws tau cawm 100% ntawm cov nas uas muaj septicemia thiab 70% ntawm cov nas uas muaj mob ntsws. Tsis tas li ntawd, kev tswj hwm lolamicin tsis tau ua rau muaj kev hloov pauv loj hauv kev sau qoob loo ntawm cov kab mob hauv plab microbiome ntawm cov nas nyob rau lub sijhawm peb-hnub kev kho mob lossis 28-hnub rov qab los.
Cov txiaj ntsig ntawm kev tshawb fawb txog tsiaj ua ntej kev kho mob no txhawb nqa thiab muab kev cia siab rau kev daws teeb meem cuam tshuam nrog kev tsom mus rau cov kab mob gram-negative tsis xaiv neeg. Nws yog ib qho pov thawj ntawm lub tswv yim tias nws muaj peev xwm tsim cov tshuaj tua kab mob uas xaiv cov kab mob gram-negative uas ua rau muaj kev phom sij thaum tiv thaiv cov kab mob hauv plab kom tsis txhob muaj kev phiv. Txawm li cas los xij, ntau xyoo ntawm kev tshawb fawb ntxiv yog qhov yuav tsum tau ua kom ntev cov kev tshawb pom.
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References:
- Muñoz, KA, Ulrich, RJ, Vasan, AK et al. Gram-negative-selective tshuaj tua kab mob uas ua rau lub plab microbiome. Xwm 630, 429–436 (2024). Published: 29 May 2024. DOI: https://doi.org/10.1038/s41586-024-07502-0
- University of Illinois Urbana-Champaign 2024. Kev tshawb fawb xov xwm - Cov tshuaj tua kab mob tshiab tua cov kab mob pathogenic, ua rau cov kab mob plab noj qab haus huv. Tshaj tawm 29 Tsib Hlis 2024. Muaj nyob ntawm https://news.illinois.edu/view/6367/668002791
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