Cov tshawb nrhiav tau pom tias nco nyob rau hauv cov laus laus tau txhim kho tom qab ib qho kev tswj hwm ntawm Klotho protein tsawg. Nws yog thawj zaug uas rov kho cov qib ntawm klotho tau pom los txhim kho kev paub hauv qhov tsis yog tib neeg primate. Qhov no yog txoj hauv kev rau kev sim tshuaj ntsuam xyuas yav tom ntej los sim yog tias kev kho mob klotho tuaj yeem ua pov thawj kev kho mob hauv cov neeg laus uas muaj dementia vim yog Alzheimer kab mob (AD).
Klotho yog ib txwm tshwm sim protein. Nws yog tsim nyob rau hauv lub raum thiab muaj nyob rau hauv peb hom. Membrane Klotho koom nrog laus thiab kev loj hlob ntawm cov kab mob ntev. Lub secreted Klotho ua raws li kev lom zem thiab hauv kev tiv thaiv lub cev thaum lub cev ntawm Klotho protein supresses cellular senescence. Nws yog hu ua Longevity factor vim hais tias ntawm nws cov anti-aging biological functions.
Cov theem ntawm Klotho cov protein ua rau muaj hnub nyoog. Ib txoj kev tshawb fawb txog tsiaj nyob rau xyoo 2015 tau pom tias cov nas uas txo qis Klotho tau nce kev laus thaum nce qib ntawm Klotho txhim kho lub neej.1. Cov txiaj ntsig zoo sib xws tau pom nyob rau hauv lwm txoj kev tshawb fawb qhia nyob rau tib lub xyoo ntawm tib neeg amyloid precursor protein (hAPP) transgenic nas - nce Klotho protein qhia txo qis kev tuag ntxov ntxov thiab neural network dysfunctions2. Cov tsiaj thwmsim no tau qhia tias Klotho cov protein ua lub luag haujlwm tseem ceeb hauv kev laus uas yog qhov tseem ceeb heev rau cov kab mob neurodegenerative feem ntau hu ua Alzheimer disease (AD).
Association ntawm Klotho nrog Alzheimer kab mob (AD) tau los ua qhov kev pom zoo los ntawm kev soj ntsuam kev soj ntsuam kev sib tham hauv xyoo tas los. Txoj kev tshawb no koom nrog 243 tus neeg mob uas muaj kab mob Alzheimer (AD) thiab kev paub txog kev noj qab haus huv. Nws tau pom tias Klotho qib hauv Cerebro-spinal fluid (CSF) tau nce siab dua ntawm kev tswj hwm kev noj qab haus huv. Cov neeg nrog dementia vim Alzheimer kab mob tau qis dua Klotho CSF. Tsis tas li ntawd, Klotho qib sib txawv hauv cov theem kho mob ntawm Alzheimer kab mob3.
Yuav kho cov qib Klotho hauv cov tib neeg nrog dementia vim Alzheimer kab mob yog ib txoj hauv kev los kho thiab tiv thaiv xws li mob? Qhov no tuaj yeem ua tau tsuas yog tom qab kev sim tshuaj ntsuam xyuas thiab kev nyab xeeb thiab cov txiaj ntsig tau pom tias muaj kev txaus siab. Tab sis lub ntsiab lus tseem ceeb ntawm qhov no tau mus txog rau qhov tsis yog tib neeg primate.
Hauv kev tshawb nrhiav4 tshaj tawm rau 03 Lub Xya Hli 2023, cov kws tshawb fawb pom tias kev nco hauv cov laus laus tau txhim kho tom qab ib qho kev tswj hwm ntawm Klotho cov protein tsawg. Nws yog thawj zaug uas rov kho cov qib ntawm klotho tau pom los txhim kho kev paub hauv qhov tsis yog tib neeg primate. Qhov no yog txoj hauv kev rau kev sim tshuaj ntsuam xyuas yog tias kev kho mob klotho tuaj yeem ua pov thawj kev kho mob hauv cov neeg laus.
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References:
- Kim J. thiab al 2015. Lub luag haujlwm lom neeg ntawm Anti-aging Protein Klotho. Phau ntawv Journal of Lifestyle Medicine 2015; 5:1-6. Tshaj tawm hauv online Lub Peb Hlis 31, 2015; DOI: https://doi.org/10.15280/jlm.2015.5.1.1
- Dubal IB thiab al. 2015. Lub neej Extension Factor Klotho Tiv thaiv kev tuag thiab txhim kho kev paub hauv hAPP Transgenic nas. Phau ntawv Journal of Neuroscience 11 Lub Ob Hlis 2015, 35 (6) 2358-2371; DOI: https://doi.org/10.1523/JNEUROSCI.5791-12.2015
- GR thiab al 2022. Association of Klotho Protein Levels and KL-VS Heterozygosity With Alzheimer Disease and Amyloid and Tau Burden. JAMA Netw Qhib. 2022; 5(11): e2243232. DOI: https://doi.org/10.1001/jamanetworkopen.2022.43232
- Castner, SA, Gupta, S., Wang, D. et al. Longevity factor klotho txhim khu kev paub hauv cov laus uas tsis yog tib neeg primates. Nat Aging (2023). https://doi.org/10.1038/s43587-023-00441-x
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