Hauv kev tshawb fawb hauv vivo tsis ntev los no ntawm Zebrafish, cov kws tshawb fawb tau ua tiav qhov kev tsim tawm ntawm cov disc hauv lub degenerated disc los ntawm kev ua kom muaj qhov endogenous Ccn2a-FGFR1-SHH signaling cascade. Qhov no qhia tias Ccn2a protein tuaj yeem siv los txhawb kev tsim kho IVD rau kev kho mob nraub qaum.
Rov qab mob yog ib qho teeb meem kev noj qab haus huv. Nws yog ib qho laj thawj tshaj plaws rau tib neeg mus nrhiav kev teem caij nrog kws kho mob. Tus mob no feem ntau yog vim degeneration ntawm intervertebral disc (IVD) uas tshwm sim ib txwm vim hnav thiab tsim kua muag los yog laus. Analgesics thiab anti-inflammatories nrog rau kev kho lub cev tam sim no yog siv los kho cov tsos mob. Nyob rau hauv cov xwm txheej hnyav, kev hloov disc lossis kev phais disc fusion tuaj yeem siv tau. Yog li ntawd, tsis muaj kev kho. Tsis paub txog kev kho mob lossis txheej txheem yuav pab tau li cas los kho disc homeostasis. Txoj kev daws teeb meem yog nyob rau hauv kev nrhiav ib txoj hauv kev los txo cov disc degeneration thiab / los yog induce disc regeneration.
Hauv kev kawm hauv vivo ntawm Zebrafish, tshaj tawm rau 6th Lub Ib Hlis 2023, cov kws tshawb nrhiav pom tias Cellular kev sib txuas lus network yam 2a (Ccn2a), a protein secreted los ntawm cov hlwb ntawm intervertebral disc induces disc regeneration nyob rau hauv cov laus degenerated discs los ntawm kev txhawb cell proliferation thiab cell ciaj sia taus los ntawm kev hloov ntawm FGFR1-SHH (Fibroblast loj hlob yam tseem ceeb receptor-Sonic Hedgehog) txoj kev.
Thaj, qhov no yog thawj zaug uas disc regeneration nyob rau hauv ib tug degenerated disc tau induced nyob rau hauv vivo los ntawm activating ib endogenous signaling cascade.
Txoj kev loj hlob no tej zaum yuav yog lub hauv paus rau kev tsim lub tswv yim tshiab los tiv thaiv cov disc degeneration los yog induce disc regeneration nyob rau hauv degenerated tib neeg discs.
***
References:
Rayrikar AW, thiab al 2023. Ccn2a-FGFR1-SHH signaling yog tsim nyog rau intervertebral disc homeostasis thiab regeneration nyob rau hauv cov neeg laus zebrafish. Kev loj hlob. Volume 150, Issue 1. Published 06 January 2023. DOI: https://doi.org/10.1242/dev.201036
***
