Thaum Lub Rau Hli 2020, RECOVERY sim los ntawm ib pawg ntawm cov kws tshawb fawb hauv Oxford University UK qhia txog kev siv dexamethasone tus nqi qis.1 rau kev kho mob hnyav rau cov neeg mob COVID-19 los ntawm kev txo qhov mob. Tsis ntev los no, cov tshuaj muaj protein ntau, hu ua Aviptadil, tau taug qab nrawm los ntawm FDA rau kev sim tshuaj ntsuam xyuas nyob rau nruab nrab. loj heev cov neeg mob COVID. Kev sim pib rau 1st Lub Xya Hli 2020 thiab cov txiaj ntsig thawj zaug tau txhawb nqa heev.
Kev sib tw yog nyob rau hauv kev tsim tshuaj muaj kev nyab xeeb thiab siv tau zoo rau kev kho mob Covid-19, uas tau cuam tshuam tag nrho lub ntiaj teb thiab ua rau muaj teeb meem kev lag luam thiab kev noj qab haus huv tseem ceeb rau ntau tshaj 200 lub teb chaws thoob plaws ntiaj teb. Txawm hais tias ob peb cov tshuaj tiv thaiv kab mob me me tau raug pom zoo los ua kev kho mob, muaj cov kev mob tshwm sim ntawm cov tshuaj me me no. Kev yos hav zoov yog nyob rau ntawm cov tshuaj muaj protein ntau uas suav nrog cov tshuaj tiv thaiv monoclonal2 uas yog qhov tshwj xeeb thiab muaj kev phiv me me. Tsis tas li ntawd, los ntawm qhov kev xav mus ntev ntawm kev tiv thaiv cov pej xeem thoob ntiaj teb, tag nrho lub ntiaj teb tau mob siab rau tos kom muaj cov tshuaj tiv thaiv zoo thiab siv tau zoo uas yuav pab txhim kho kev tiv thaiv kab mob tiv thaiv kab mob thiab ua rau lub neej rov qab mus rau qhov qub li qub ua ntej COVID-19.
Aviptadil yog ib qho kev tsim ntawm hluavtaws Vasoactive plab hnyuv Polypeptide (VIP). VIP tau pom thawj zaug hauv xyoo 1970 los ntawm Dr Sami Said, kws kho mob ntsws pulmonary. Nws yog tam sim no nyob rau hauv siab concentrations nyob rau hauv lub ntsws qhov chaw uas nws muaj kev koom tes nyob rau hauv so ntawm cov hlab ntsha thiab pulmonary hlab ntsha. VIP kuj tau raug txheeb xyuas tias yog qhov muaj zog tiv thaiv kab mob, uas ua haujlwm los ntawm kev tswj hwm kev tsim tawm ntawm ob qho tib si los tiv thaiv thiab tiv thaiv kab mob.3 thiab ua haujlwm los ntawm kev thaiv cov kab mob cytokines.
Kev siv Aviptadil hauv qhov kev sim tshuaj ntsuam xyuas tsis ntev los no tau ua rau cov neeg mob rov zoo los ntawm kev ua pa tsis ua haujlwm hauv cov neeg mob hnyav Covid-19. Thaum siv cov tshuaj, nws tau tshem ntawm lawv lub ntsws o, txhim kho lawv cov ntshav oxygen thiab txo cov cim inflammatory ntau dua 50% hauv ntau dua 15 tus neeg mob.4. Txawm li cas los xij, cov ntaub ntawv ntxiv los ntawm kev sim tshuaj ntsuam xyuas yuav tsum tsim kom muaj kev nyab xeeb thiab kev ua tau zoo ntawm Aviptadil hauv cov neeg mob ntau dua nrog rau cov neeg mob uas tsis tshua muaj mob hnyav los xyuas kom meej tias cov kev soj ntsuam zoo sib xws tau pom.
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References:
- Soni, R, 2020. Dexamethasone: Puas muaj cov kws tshawb fawb pom muaj kev kho mob rau cov neeg mob COVID-19 mob hnyav? Kev tshawb fawb European. Published on August 14, 2020. Muaj nyob online ntawm https://www.scientificeuropean.co.uk/covid-19/dexamethasone-have-scientists-found-cure-for-severely-ill-covid-19-patients/
- Soni, R, 2020. Monoclonal Antibodies thiab Protein Based Drugs tuaj yeem siv los kho cov neeg mob COVID-19. Kev tshawb fawb European. Published on August 14, 2020. Muaj nyob online ntawm https://www.scientificeuropean.co.uk/covid-19/monoclonal-antibodies-and-protein-based-drugs-could-be-used-to-treat-covid-19-patients/
- Delgado M, Abad C, Martinez C, Juarranz MG, Arranz A, Gomariz RP, Leceta J. Vasoactive plab hnyuv peptide nyob rau hauv lub cev: muaj peev xwm kho lub luag hauj lwm nyob rau hauv inflammatory thiab autoimmune kab mob. J Mol Med (2002) 80:16–24. DOI: https://doi.org/10.1007/s00109-001-0291-5
- Youssef JG, Zahiruddin F, Al-Saadi M, Yau S, Goodarzi A, Huang HJ, Javitt JC. Daim ntawv qhia luv luv: Kev kho mob sai sai los ntawm qhov tseem ceeb COVID-19 nrog kev ua pa tsis ua haujlwm hauv lub ntsws hloov neeg mob kho nrog Intravenous Vasoactive plab hnyuv Peptide. Preprints 2020, 2020070178 DOI: https://doi.org/10.20944/preprints202007.0178.v2
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