Tshuaj tua kab mob kuj tshwj xeeb yog cov kab mob Gram-negative tau ze li tsim muaj teeb meem zoo li qhov xwm txheej. Cov tshuaj tua kab mob tshiab Zosurabalpin (RG6006) qhia cov lus cog tseg. Nws tau pom tias muaj txiaj ntsig zoo tiv thaiv tshuaj tiv thaiv, kab mob Gram-negative CRAB hauv kev tshawb fawb ua ntej.
Antimicrobial tsis kam (AMR), uas tau tsav los ntawm kev siv tsis raug thiab siv ntau dhau ntawm cov tshuaj tua kab mob, yog ib qho kev pheej hmoo rau pej xeem kev noj qab haus huv.
Kab mob los ntawm kab mob Gram-negative yog tshwj xeeb yog hais txog. Nws tsis yooj yim rau feem ntau tshuaj tua kab mob kom hla ob sab hauv thiab sab nrauv daim nyias nyias muaj nyob rau hauv pawg kab mob no kom nkag mus rau cov kab mob hauv lub hlwb kom pom cov kab mob bactericidal. Tsis tas li ntawd, cov kab mob Gram-negative tau sau ntau yam tsis txaus ntseeg tshuaj tua kab mob kuj.
Acinetobacter baumannii, cov yog kab mob Gram-negative. Kev kis kab mob los ntawm ib qho ntawm nws cov kab mob hu ua 'carbapenem-resistant Acinetobacter baumannii' (CRAB) yog ib qho nyuaj rau kev kho mob siv muaj. tshuaj tua kab mob. Muaj ib qho kev xav tau ceev kom muaj txiaj ntsig tshuaj tua kab mob tawm tsam CARB raws li kev tuag tus nqi siab (kwv yees li 40% -60%) uas yog vim qhov tsis muaj txiaj ntsig zoo tshuaj tua kab mob. Kev nce qib mus rau lub hom phiaj no tau tshaj tawm.
Cov kws tshawb fawb tau txheeb xyuas cov chav kawm tshiab ntawm tshuaj tua kab mob uas yog, tethered macrocyclic peptides (MCPs) uas muaj zog tiv thaiv kab mob Gram –ve A. baumannii suav nrog CARB los ntawm kev thaiv kev thauj cov kab mob lipopolysaccharide los ntawm daim nyias nyias mus rau txheej membrane.
Zosurabalpin (RG6006) yog ib qho tshuaj tua kab mob Cov neeg sib tw uas yog 'tethered macrocyclic peptides (MCPs)' chav kawm. Hauv pre-clinical Kev sim nrog rau kev tshawb fawb hauv vitro thiab hauv vivo kev tshawb fawb ntawm cov qauv tsiaj, Zosurabalpin tau pom tias muaj txiaj ntsig zoo tiv thaiv cov tshuaj tiv thaiv kab mob ntawm 'carbapenem-resistant Acinetobacter baumannii' (CRAB) los ntawm ntau thaj tsam. Nws yeej kov yeej tshuaj tua kab mob-kev tiv thaiv mechanism ntawm CARB tawm tswv yim Zosurabalpin muaj peev xwm.
Yog li ntawd, tib neeg clinical kev sim tau pib los xyuas kom muaj kev nyab xeeb thiab ua tau zoo Zosurabalpin hauv kev kho cov kab mob kis tau los ntawm CRAB.
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References:
- Zampaloni, C., Mattei, P., Bleicher, K. et al. Ib tug tshiab tshuaj tua kab mob chav kawm tsom rau lipopolysaccharide transporter. Xwm (2024). https://doi.org/10.1038/s41586-023-06873-0
- Hawj S., thiab al 2023. Kev Ua Haujlwm ntawm Novel Antibiotic Zosurabalpin (RG6006) tawm tsam Soj ntsuam Acinetobacter Isolates los ntawm Tuam Tshoj, Qhib Rooj Sib Tham Kab Mob Sib Kis, Volume 10, Issue Supplement_2, Kaum Ob Hlis 2023, ofad500.1754, https://doi.org/10.1093/ofid/ofad500.1754
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 shows promises. It has been found to be effective against drug-resistant, Gram-negative bacteria CRAB in pre-clinical studies.){kind=link}