Ib txoj hauv kev tiv thaiv kab mob tiv thaiv kab mob tiv thaiv kab mob tshwj xeeb tau tsim los uas tsom rau cov qog nqaij hlav uas muaj cov qog nqaij hlav.
Mob qog nqaij hlav qe menyuam yog xya feem ntau cancer nyob rau hauv cov poj niam thoob ntiaj teb. Lub zes qe menyuam yog ob lub qog uas tsim cov qe hauv poj niam thiab tseem tsim cov poj niam cov tshuaj hormones estrogen thiab progesterone. Ovarian cancer tshwm sim thaum cov hlwb txawv txav hauv zes qe menyuam pib loj hlob dhau los tswj thiab ua rau qog. Cov qog nqaij hlav zes qe menyuam feem ntau tsis muaj tsos mob thaum ntxov, yog li qhov no cancer yog feem ntau siab heev thaum nws raug kuaj. Qhov kev muaj sia nyob tsib xyoos rau qhov no cancer yog li ntawm 30 mus rau 50 feem pua. Yog tias tsis kho, cov qog tuaj yeem kis mus rau lwm qhov ntawm lub cev, hu ua metastatic zes qe menyuam cancer.
Immunotherapy los kho mob qog noj ntshav ntawm zes qe menyuam
antibody Kev kho mob, ib hom kev tiv thaiv kab mob (lossis immunotherapy) yog 'kev kho lub hom phiaj' uas siv cov tshuaj tiv thaiv kab mob los txheeb xyuas cov hom phiaj kab mob, txuas rau cov tshuaj tshwj xeeb ntawm cancer cell thiab ces tua lawv los yog hu xov tooj tiv thaiv kab mob los tua lawv. Malignant loj hlob hauv zes qe menyuam cancer feem ntau tsis muaj kua los yog hlwv tab sis tsim cov qog nqaij hlav. Ib qho teeb meem loj hauv kev tiv thaiv kab mob rau zes qe menyuam cancer yog tias peb lub cev tiv thaiv kab mob tsis tuaj yeem nkag mus rau cov qog nqaij hlav zoo. Txoj kev vam meej ntawm kev tiv thaiv kab mob yog txwv tsis pub nyob rau hauv cov qog nqaij hlav thiab qhov no ua rau tsis zoo rau lwm txoj kev tiv thaiv kab mob qog noj ntshav. Cov kws tshawb fawb los ntawm University of Virginia tau tsim cov tshuaj tiv thaiv kab mob tshiab los tua zes qe menyuam cancer los ntawm kev sim kov yeej cov teeb meem no. Hauv lawv txoj kev tshawb fawb luam tawm hauv Cancer Cell, cov kws sau ntawv hais tias qhov teeb meem tseem ceeb yog tshwm sim los ntawm kev ua phem microenvironment ntawm cov qog nqaij hlav uas ua rau nws nyuaj rau cov tshuaj tiv thaiv kab mob kom ncav cuag thiab tua. cancer hlwb. Qhov microenvironment no tsis tshua muaj oxygen thiab nyob rau hauv cov ntaub ntawv ntawm zes qe menyuam cancer ib txheej loj receptors tsim ib lub laj kab tiv thaiv nyob ib ncig ntawm cov qog nqaij hlav cancer. Xws li ib puag ncig nyuaj txwv kev ua ntawm lub cev tiv thaiv kab mob txawm tias tom qab lawv tuaj txog ntawm no. Txhawm rau daws qhov teeb meem, cov kws sau ntawv tau tsim cov tshuaj tiv thaiv nrog ob "lub taub hau" thiab tau xa mus rau lawv txoj kev ua "ib leeg-tus neeg saib xyuas dual-kev tshwj xeeb tsom" piv txwv li cov tshuaj tiv thaiv no ntaus ob lub hom phiaj ntawm zes qe menyuam. cancer cell. Thawj lub hom phiaj yog folate receptor alpha-1 receptor hu ua FOLR1 - uas tau qhia ntau heev hauv zes qe menyuam. cancer thiab yog ib lub cim tsim rau kev ua tsis zoo. Antibody siv FOLR1 rau 'anchoring' rau cov qog nqaij hlav cancer. Lub hom phiaj thib ob yog 'kev tuag receptor 5' ntawm cancer cov cell uas cov tshuaj tiv thaiv kab mob khi ua rau cancer cell tuag. Qhov no engineered antibody yog ntau tshaj 100 lub sij hawm zoo nyob rau hauv tua cov qog nqaij hlav cancer piv rau cov tshuaj tiv thaiv uas tam sim no nyob rau hauv kev sim tshuaj. Cov kws tshawb fawb tau siv cov ntaub ntawv los ntawm cov ntaub ntawv kho mob loj uas muaj rau kev tiv thaiv kab mob qog noj ntshav ntawm zes qe menyuam.
Txoj hauv kev zoo sib xws hauv nas kuj zam cov teeb meem toxicity uas yog ib qho teeb meem tshwm sim hauv cov tshuaj tiv thaiv yav dhau los. Piv txwv li, lub siab toxicity yog ib qho teeb meem vim hais tias cov tshuaj tiv thaiv tawm hauv cov hlab ntsha sai thiab pib sau rau hauv daim siab. Cov tshuaj tiv thaiv hauv txoj kev tshawb fawb tam sim no nyob hauv cov qog thiab yog li 'nyob deb' ntawm daim siab. Txoj hauv kev tseem nyob rau theem pib ntawm kev kho mob tab sis cov kws tshawb fawb xav kom sim qhov kev sim no hauv tib neeg. Yog tias ua tiav, nws tuaj yeem siv rau lwm hom cancer thiab nyob rau hauv uas cov qog nqaij hlav muaj xws li lub mis thiab prostrate cancer.
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Qhov (s)
Shivange G et al. 2018. Ib Tus Neeg Sawv Cev Ib Leeg Ob-Specificity Targeting ntawm FOLR1 thiab DR5 raws li lub tswv yim zoo rau Ovarian cancer. Cancer Cell. 34 (2)
https://doi.org/10.1016/j.ccell.2018.07.005
