Kev kuaj ntshav tshiab rau qhov mob tau tsim kho uas tuaj yeem pab muab cov hom phiaj kho raws li qhov mob hnyav
Tus kws kho mob ntsuas tus neeg mob mob kev hnov lus yog vim nws feem ntau txiav txim siab los ntawm tus neeg mob qhov kev tshaj tawm tus kheej lossis kev kuaj mob. Qhov laj thawj tseem ceeb ntawm kev kis tus kab mob opioid nyob rau ntau lub tebchaws yog cov tshuaj noj ntau dhau ntawm cov tshuaj kho mob uas ua rau muaj kev quav tshuaj ntawm cov tshuaj no. Kev tso npe ntau dhau tshwm sim vim tsis muaj cov txheej txheem los ntsuas qhov mob. Kev sib txuas lus zoo ntawm 'theem ntawm qhov mob' tsis tshua muaj tshwm sim hauv qhov chaw kho mob tshwj xeeb rau cov menyuam yaus thiab cov neeg laus. Cov mob cov tshuaj tau txuas mus ntxiv rau txhua qib mob thiab qhov no tau tsim teeb meem loj. Qhov mob tsis kho tuaj yeem cuam tshuam rau lub neej zoo yog li kev kho kom haum rau qhov mob yog qhov xav tau ntawm lub sijhawm.
Txheeb xyuas biomarkers rau qhov mob
Nyob rau hauv ib txoj kev tshawb nrhiav tau luam tawm nyob rau hauv xwm phau ntawv journal Molecular Psychiatry, ib tug thawj puas prototype ntshav xeem tau tsim los ntawm Indiana University Tsev Kawm Ntawv ntawm Tshuaj, Tebchaws Asmeskas uas tuaj yeem ua haujlwm yog tias tsis suav tag nrho ntsuas qhov hnyav ntawm tus neeg mob qhov mob nrog qhov tseeb zoo dua. Cov kws tshawb fawb tau tso npe rau ntau pua tus neeg koom nrog uas yog cov neeg mob puas siab puas ntsws - ib pab pawg muaj kev pheej hmoo siab rau qhov mob uas muaj kev hnov qab thiab nkag siab txog qhov mob. Cov kws tshawb fawb tau txheeb xyuas cov noob qhia biomarkers hauv lub ntshav (xws li kos npe lossis tus ntiv tes uas yog qhov tshwj xeeb) uas tuaj yeem txiav txim siab qhov mob hnyav. Cov biomarkers no yog cov molecules uas tuaj yeem cuam tshuam qhov mob hnyav, piv txwv li cov piam thaj hauv ntshav yog biomarker rau ntshav qab zib. Qee tus biomarkers zoo li MFAP3 tsis muaj pov thawj yav dhau los ntawm kev koom tes hauv kev mob thaum muaj ntau lwm tus yog lub hom phiaj ntawm cov tshuaj uas twb muaj lawm.
Predicting natural tshuaj
Cov kws tshawb fawb tau siv tshuaj bioinformatics repurposing tsom xam kom phim qhov mob biomarkers nrog cov tshuaj uas twb muaj lawm, cov tshuaj thiab cov ntsiab lus ntuj tsim nyob rau hauv daim ntawv sau tshuaj. Kev tshuaj xyuas pom tau tias muaj cov tshuaj lead ua tau zoo uas yuav normalize qhov mob kos npe. Cov tebchaw no suav nrog ob qho tshuaj tiv thaiv kev nyuaj siab nrog rau cov khoom siv ntuj xws li Vitamin B6 thiab Vitamin B12. Cov npe luv luv yog cov tshuaj uas tsis yog opioid lossis cov tshuaj sib xyaw. Cov mob biomarkers kuj tuaj yeem kwv yees thaum tus neeg mob yuav hnov mob tom ntej thiab zoo li yuav mus ntsib kws kho mob. Qee cov biomarkers tau pom tias yog universal thiab qee qhov tshwj xeeb rau poj niam txiv neej.
Cov ntaub ntawv no los ntawm ib qho yooj yim ntshav kev ntsuam xyuas yuav pab tau los ntsuas yog tias tus neeg mob raug mob los ntawm qhov mob mus ntev. Kev kho mob tuaj yeem muab qhov tseeb thiab ntau yam tshwj xeeb tshaj yog rau mob taub hau, fibromyalgia thiab lwm yam. Rau txhua txoj kev kho mob lub hom phiaj yog nrhiav cov tshuaj zoo uas muaj kev phiv tsawg. Txoj kev tshawb no yog thawj kauj ruam ntawm cov tshuaj precision rau qhov mob xws li kev kho mob tus kheej thiab nws tuaj yeem hloov txoj kev mob los ntawm kev kho mob.
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Qhov (s)
Niculescu AB et al 2019. Towards precision medicine for pain: diagnostic biomarkers and repurposed drug. Molecular Psychiatry. https://doi.org/10.1038/s41380-018-0345-5
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