Cov kws tshawb fawb tau muab cov khoom siv nanomaterial uas muaj cov cuab yeej tiv thaiv kab mob rau hauv cov khoom sib xyaw ua ke. Cov khoom ntim tshiab no tuaj yeem tiv thaiv kev rov tshwm sim ntawm cov kab noj hniav uas tshwm sim los ntawm cov kab mob virulent.
Hniav lwj (hu ua kho hniav kab noj hniav los yog kab noj hniav) yog ib qho tshwm sim heev thiab dav cov kab mob kab mob nyob rau hauv cov me nyuam mus kawm ntawv thiab cov neeg laus. Muaj kab mob kab mob zoo li Cov kab mob Streptococcus mutans accumulate nyob rau saum npoo ntawm cov hniav thiab pib yaj cov ntaub so ntswg. Ib zaug kab mob nyob rau ntawm tus hniav nto, nws ua rau cov hniav tom qab (los yog rov tshwm sim) ntawm cov npoo ntawm cov hniav. filling vim kev tsim cov kua qaub los ntawm kab noj hniav-ua rau kab mob uas tam sim no nyob rau hauv lub interface ntawm kev kho hniav filling thiab cov hniav. Cov hniav lwj uas tshwm sim los ntawm cov kab mob yog lub luag haujlwm rau kev ua tsis tiav ntawm cov khoom kho hniav uas cuam tshuam rau 100 lab tus neeg mob txhua xyoo. Cov hniav rov ua dua thiab cov hniav lwj ua rau cov hniav tshem tawm thiab kho cov kwj dej hauv paus.
Nyob rau hauv lub sij hawm ua ntej, amalgam fillings uas muaj hlau alloys tau siv rau kev kho hniav. Cov filling no tau muaj qee yam Tshuaj tua kab mob cov nyhuv tab sis kuj muaj qhov tsis zoo ntawm cov xim xim, mercury toxicity thiab tsis muaj adhesion rau cov hniav. Tam sim no cov khoom sib xyaw tau siv rau hauv cov ntaub ntawv kho hniav, txawm li cas los xij, lawv tsis muaj cov khoom siv tshuaj tua kab mob uas yog qhov tsis zoo. Tsis tas li ntawd, maj mam tso tawm ntawm cov neeg ua haujlwm soluble los ntawm cov resin cuam tshuam rau lawv cov khoom siv tshuab ua rau cov khoom ntxeem tau lossis tsis muaj zog. Ntau ntawm cov ntaub ntawv sib xyaw ua ke tau sim yog lub sijhawm txwv thiab kuj tseem tuaj yeem ua rau muaj mob rau cov ntaub so ntswg nyob sib ze tshwj xeeb vim lawv xav tau ntau npaum li cas. Resin-based composite fillings uas nthuav tawm cov kab mob inhibitory ua haujlwm tuaj yeem cuam tshuam kev loj hlob ntawm cov kab mob hauv qhov ncauj xws li cov hniav lwj.
Hauv kev tshawb fawb luam tawm rau lub Tsib Hlis 28 hauv ACS Applied Materials thiab Interfaces, cov kws tshawb fawb piav qhia txog cov khoom siv txhim kho tshiab uas muaj lub zog zoo Tshuaj tua kab mob muaj peev xwm uas tuaj yeem siv rau kev kho hniav tshiab los tiv thaiv cov hniav lwj. Tib pab pawg ntawm cov kws tshawb fawb tau tshawb pom hauv lawv txoj haujlwm ua ntej uas nws tus kheej sib sau ua ke lub tsev thaiv Fmoc-pentafluro-L-phenylalanine-OH (Fmoc) muaj zog Tshuaj tua kab mob thiab kuj muaj anti-inflammatory zog. Thiab, nws muaj ob qho tib si haumxeeb thiab cov qauv subparts. Hauv txoj kev tshawb fawb tam sim no, cov kws tshawb fawb tau koom ua ke Fmoc nanoassemblies hauv cov khoom siv kho hniav uas siv cov txheej txheem tshiab tsim los ntawm lawv.
cov Tshuaj tua kab mob Lub peev xwm ntawm cov khoom ntim tshiab no tau soj ntsuam tom qab. Cov kws tshawb fawb kuj tau txheeb xyuas nws lub zog txhua yam, cov khoom kho qhov muag thiab biocompatibility. Thaum resin-raws li composites ntxiv nrog antibacterial nano-assemblies nws tau txais lub peev xwm los inhibit thiab cuam tshuam kev loj hlob thiab kev vam meej ntawm kab mob. Cov khoom siv tshiab tsis muaj tshuaj lom thiab cov khoom siv kho qhov muag lossis kho qhov muag ntawm nanaoassemblies tseem tsis cuam tshuam los ntawm kev sib koom ua ke. Cov tshuaj tua kab mob tiv thaiv kab mob S mutans yuav tsum tau noj tsawg heev ntawm cov khoom tshiab.
Txoj kev kawm tam sim no qhia tau hais tias Tshuaj tua kab mob Kev ua haujlwm ntawm Fmoc nanoassemblies thiab nws cov kev ua haujlwm sib koom ua ke rau hauv cov hniav sib xyaw ua ke los tsim cov khoom siv biocompatible resin composite amalgamated. Cov khoom ntim tshiab yog qhov zoo nkauj saib, mechanically rigid, muaj siab purity, yog pheej yig thiab yuav muab tau yooj yim embedded nyob rau hauv resin-raws li cov ntaub ntawv filling.
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{Koj tuaj yeem nyeem cov ntawv tshawb fawb thawj zaug los ntawm nyem rau ntawm DOI qhov txuas tau muab hauv qab no hauv cov npe ntawm cov khoom raug suav nrog}
Qhov (s)
Schnaider, L. et al. 2019. Enhanced Nanoassembly-Incorporated Antibacterial Composite Materials. ACS Applied Materials & Interfaces. 11 (24). https://doi.org/10.1021/acsami.9b02839
