Cov kws tshawb fawb tau muab cov khoom siv nanomaterial uas muaj cov cuab yeej tiv thaiv kab mob rau hauv cov khoom sib xyaw ua ke. Cov khoom ntim tshiab no tuaj yeem tiv thaiv kev rov tshwm sim ntawm cov kab noj hniav uas tshwm sim los ntawm cov kab mob virulent.
Kev lwj hniav (hu ua qhov hniav lwj lossis kab mob lwj hniav) yog ib yam kab mob uas tshwm sim ntau thiab dav heev rau cov menyuam yaus thiab cov neeg laus uas mus kawm ntawv. Cov kab mob loj xws li Streptococcus mutans sib sau ua ke rau ntawm qhov hniav thiab pib yaj cov nqaij tawv. Thaum cov kab mob nyob rau ntawm qhov hniav, nws ua rau muaj kev lwj hniav thib ob (lossis rov tshwm sim) ntawm ntug ntawm qhov kho hniav vim yog kev tsim cov kua qaub los ntawm cov kab mob ua rau muaj qhov hniav lwj uas tam sim no nyob hauv qhov sib txuas ntawm qhov kho hniav thiab tus hniav. Kev lwj hniav los ntawm cov kab mob yog lub luag haujlwm rau kev ua tsis tiav ntawm cov khoom kho hniav uas cuam tshuam rau 100 lab tus neeg mob txhua xyoo. Kev lwj hniav rov tshwm sim thiab kev lwj ua rau rho hniav thiab kev kho cov hauv paus hniav.
Yav dhau los, cov khoom siv amalgam uas muaj cov hlau sib xyaw tau siv rau kev kho hniav. Cov khoom siv no muaj qee yam kev ua haujlwm tua kab mob tab sis kuj muaj qhov tsis zoo ntawm cov xim khov kho, tshuaj lom mercury thiab tsis lo rau cov hniav. Tam sim no cov composite resins siv rau hauv cov ntaub ntawv kho hniav, txawm li cas los xij, lawv tsis muaj cov khoom tua kab mob uas yog qhov tsis zoo loj. Tsis tas li ntawd, kev tso tawm maj mam ntawm cov neeg sawv cev yaj los ntawm cov resin cuam tshuam rau lawv cov khoom siv kho tshuab ua rau cov resin porous lossis tsis muaj zog. Ntau yam ntawm cov ntaub ntawv sib xyaw ua ke tau sim yog lub sijhawm txwv thiab kuj tseem yuav muaj tshuaj lom rau cov ntaub so ntswg nyob ze tshwj xeeb tshaj yog vim lawv xav tau cov tshuaj ntau. Cov khoom siv sib xyaw ua ke ua los ntawm cov resin uas ua rau muaj kev ua haujlwm tiv thaiv kab mob tuaj yeem tiv thaiv kev loj hlob ntawm cov kab mob hauv qhov ncauj dav dav xws li cov hniav lwj.
Hauv kev tshawb fawb luam tawm rau lub Tsib Hlis 28 hauv ACS Applied Materials and Interfaces , cov kws tshawb fawb piav qhia txog cov khoom siv tshiab uas muaj peev xwm tua kab mob uas siv tau rau kev kho hniav tshiab kom tiv thaiv kev lwj hniav rov qab. Tib pab pawg kws tshawb fawb tau pom hauv lawv txoj haujlwm ua ntej tias cov khoom siv sib dhos ua ke Fmoc-pentafluro-L-phenylalanine-OH (Fmoc) muaj cov khoom tua kab mob thiab tiv thaiv kev o. Thiab, nws muaj ob qho tib si ua haujlwm thiab cov qauv. Hauv kev tshawb fawb tam sim no, cov kws tshawb fawb tau koom ua ke Fmoc nanoassemblies hauv cov khoom siv kho hniav ua los ntawm cov resin siv cov txheej txheem tshiab tsim los ntawm lawv.
Cov peev xwm tua kab mob ntawm cov khoom siv tshiab no tau raug soj ntsuam tom qab. Cov kws tshawb fawb kuj tau tshuaj xyuas nws lub zog kho tshuab, cov khoom siv kho qhov muag thiab biocompatibility. Thaum cov khoom sib xyaw ua ke raws li resin raug ntxiv nrog cov nano-assemblies tua kab mob nws tau txais lub peev xwm los tiv thaiv thiab cuam tshuam kev loj hlob thiab kev muaj sia nyob ntawm cov kab mob . Cov khoom siv tshiab tsis muaj tshuaj lom thiab cov khoom siv kho tshuab lossis kho qhov muag ntawm cov nanoassemblies tseem tsis cuam tshuam los ntawm kev koom ua ke. Cov haujlwm tua kab mob tawm tsam cov kab mob S mutans xav tau cov tshuaj tsawg heev ntawm cov khoom siv tshiab.
Daim kev tshawb fawb tam sim no qhia txog kev ua haujlwm tiv thaiv kab mob ntawm Fmoc nanoassemblies thiab nws txoj kev koom ua ke rau hauv cov khoom siv kho hniav kom tsim tau cov khoom siv sib xyaw ua ke uas sib haum nrog cov khoom siv biocompatible resin. Cov khoom siv tshiab no zoo nkauj, ruaj khov, muaj kev ntshiab siab, pheej yig thiab tuaj yeem yooj yim muab tso rau hauv cov khoom siv ua los ntawm cov resin.
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{Koj tuaj yeem nyeem cov ntawv tshawb fawb thawj zaug los ntawm nyem rau ntawm DOI qhov txuas tau muab hauv qab no hauv cov npe ntawm cov khoom raug suav nrog}
Qhov (s)
Schnaider, L. et al. 2019. Cov Khoom Siv Sib xyaw ua ke uas muaj Nanoassembly-Incorporated Antibacterial. ACS Applied Materials & Interfaces. 11 (24). https://doi.org/10.1021/acsami.9b02839
