Insulin-zoo li kev loj hlob zoo li qub 1 (IGF-1) yog ib qho tseem ceeb ntawm kev loj hlob uas ua rau muaj ntau yam kev loj hlob ntawm cov tshuaj hormones loj hlob (GH) los ntawm GH qhov stimulation ntawm IGF-1 tso tawm ntawm lub siab.1. IGF-1 signaling txhawb kev loj hlob thiab kev kis mob qog noj ntshav thiab cov tshuaj tau tsim los rau lub hom phiaj ntawm IGF-1 receptor (IGF1R) kom txo tau IGF-1 signaling, txawm tias tsis muaj txiaj ntsig vim tsis kam tiv thaiv cov tshuaj tau tsim hauv cov neeg mob.2. IGF-1 yog tsim los ua ib qho kev pheej hmoo rau prostate cancer thiab qib ntshav siab ntawm IGF-1 yog txuam nrog ntau hom qog nqaij hlav sib txawv2. Txawm li cas los xij, vim nws txoj kev loj hlob txhawb kev cuam tshuam, suav nrog hauv lub hlwb, txo IGF-1 signaling nyob rau hauv lub hlwb yog txuam nrog nce Alzheimer's kab mob (AD) thiab dementia txaus ntshai, kev txawj ntse poob, kev ntxhov siab thiab kev nyuaj siab.2 qhia txog kev lag luam tawm ntawm kev paub txog kev ua haujlwm thiab kev pheej hmoo mob qog noj ntshav.
Cov nas nrog txo cov ntshav IGF-1 muaj kev paub tsis meej uas tau thim rov qab thaum IGF-1 tau muab rau cov nas2. Ob qho tib si insulin receptor (IR) thiab IGF1R txhawb nqa kev faib tawm ntawm tes thiab yog li ntawd kuj muaj kev loj hlob qog noj ntshav2. Kev kawm thiab kev nco yuav tsum muaj cov tshuaj insulin / IGF-1 thiab nce IGF-1 muaj feem cuam tshuam rau kev txhim kho kev nco thiab nce ntim ntawm hippocampus2. Tsis tas li ntawd, hauv Parkinson's disease (PD) cov neeg mob uas muaj ntshav qab zib tsawg IGF-1, lawv muaj kev ua haujlwm tsis zoo ntawm cov dej num kuaj kev txawj ntse.2. Txawm li cas los xij, qhov txaus siab IGF-1 kuj tseem yuav qeeb tshem tawm ntawm beta-amyloid plaque uas ua rau AD.2, tab sis nws zoo nkaus li los ntawm cov pov thawj uas IGF-1 feem ntau tseem ceeb heev rau kev paub, pro-neurogenesis thiab neuroprotective.
Ib qho piv txwv meej ntawm qhov kev lag luam tawm no yog qhov txo qis AD txaus ntshai ntawm cancer cov neeg mob, thiab tseem hais tias cov neeg mob qog nqaij hlav laus muaj kev nco zoo dua nrog qis qis ntawm kev nco ua haujlwm2. Yog li ntawd, nws zoo li muaj kev nyab xeeb rau extrapolate qhov ntawd IGF-1, zoo li feem ntau, muaj cov txiaj ntsig thiab kev pheej hmoo cuam tshuam nrog nws thiab tsis muaj txoj hauv kev yooj yim los ua "kev noj qab haus huv" los ntawm kev tswj hwm IGF-1 los ntawm kev hloov pauv hauv kev ua neej xws li kev yoo mov thiab kev txwv lub zog kom txo qis nws cov ntshav cov ntshav, vim tias txo cov ntshav qab zib yuav muaj. Kev paub tsis meej txog qhov tshwm sim ua rau ib tus neeg paub txog "tsis zoo".
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References:
- Laron Z. (2001). Insulin-zoo li kev loj hlob 1 (IGF-1): ib qho kev loj hlob hormone. molecular pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311
- Rosenzweig SA (2020). Kev nce qib txuas ntxiv ntawm Insulin-zoo li Kev Loj Hlob Factor Signaling. F1000Res Tshawb, 9, F1000 Kws qhia ntawv Rev-205. https://doi.org/10.12688/f1000research.22198.1
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 is a prominent growth factor which conducts many of the growth-promoting effects of growth hormone (GH) through GH's stimulation of IGF-1 release from the liver.1. IGF-1 signalling promotes growth and spread of cancer and drugs have been developed to target the IGF-1 receptor (IGF1R) to reduce IGF-1 signalling, although ineffective due to resistance to the drugs being developed in patients2. IGF-1 is designated to be a risk factor for prostate cancer and high serum levels of IGF-1 are associated with a variety of different cancers){kind=link}