Insulin-zoo li kev loj hlob yam 1 (IGF-1) yog ib qho tseem ceeb ntawm kev loj hlob yam uas ua rau muaj ntau yam kev loj hlob ntawm cov tshuaj hormones loj hlob (GH) los ntawm GH txoj kev txhawb nqa ntawm IGF-1 tso tawm los ntawm lub siab. 1. IGF-1 signalling txhawb kev loj hlob thiab kev kis tus kab mob qog noj ntshav thiab cov tshuaj tau tsim los tsom rau IGF-1 receptor (IGF1R) kom txo IGF-1 signaling, txawm hais tias tsis muaj txiaj ntsig vim muaj kev tiv thaiv cov tshuaj uas tau tsim hauv cov neeg mob 2. IGF-1 tau raug xaiv los ua ib qho kev pheej hmoo rau mob qog noj ntshav prostate thiab cov ntshav siab ntawm IGF-1 cuam tshuam nrog ntau yam mob qog noj ntshav sib txawv 2. Txawm li cas los xij, vim nws cov teebmeem txhawb kev loj hlob, suav nrog hauv lub hlwb, txo qis IGF-1 signaling hauv lub hlwb cuam tshuam nrog kev nce ntxiv ntawm tus kab mob Alzheimer's (AD) thiab kev pheej hmoo ntawm kev puas hlwb, kev poob qis ntawm kev paub, kev ntxhov siab thiab kev nyuaj siab 2 qhia txog kev pauv pauv ntawm kev ua haujlwm ntawm kev paub thiab kev pheej hmoo ntawm mob qog noj ntshav.
Cov nas uas muaj cov tshuaj IGF-1 tsawg dua muaj cov teeb meem kev paub uas raug thim rov qab thaum IGF-1 raug muab rau cov nas 2. Ob qho tib si insulin receptor (IR) thiab IGF1R txhawb nqa kev faib cell thiab yog li ntawd kuj tseem muaj kev loj hlob ntawm mob qog noj ntshav 2. Kev kawm thiab kev nco qab xav tau insulin/IGF-1 signaling thiab kev nce IGF-1 tau cuam tshuam nrog kev txhim kho kev nco qab thiab kev nce ntxiv ntawm hippocampus 2. Ntxiv mus, hauv cov neeg mob Parkinson tus kab mob (PD) uas muaj cov tshuaj IGF-1 qis hauv cov ntshav, lawv muaj kev ua tau zoo tsis zoo ntawm cov haujlwm sim kev ua haujlwm ntawm kev paub 2. Txawm li cas los xij, qhov nthuav yog IGF-1 kuj tseem yuav qeeb qeeb ntawm beta-amyloid plaque uas pab txhawb rau AD 2 , tab sis nws zoo li los ntawm cov pov thawj tias IGF-1 feem ntau yog qhov tseem ceeb pro-cognition, pro-neurogenesis thiab neuroprotective.
Ib qho piv txwv meej ntawm qhov kev pauv no yog qhov txo qis kev pheej hmoo AD ntawm cov neeg mob qog noj ntshav , thiab tseem muaj cov neeg mob qog noj ntshav laus dua muaj kev nco qab zoo dua nrog qhov txo qis ntawm kev ua haujlwm nco qab 2. Yog li, nws zoo li muaj kev nyab xeeb los kwv yees tias IGF-1 , zoo li feem ntau yam, muaj cov txiaj ntsig thiab kev pheej hmoo cuam tshuam nrog nws thiab tias tsis muaj txoj hauv kev yooj yim los ua "noj qab nyob zoo" los ntawm kev tswj hwm IGF-1 los ntawm kev hloov pauv hauv lub neej xws li kev yoo mov thiab kev txwv lub zog kom txo qis nws cov concentration hauv cov ntshav, vim tias kev txo cov concentration hauv cov ntshav yuav muaj cov txiaj ntsig tsis xav tau ua rau ib tus neeg "tsis noj qab nyob zoo".
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References:
- Laron Z. (2001). Insulin-zoo li kev loj hlob 1 (IGF-1): ib qho kev loj hlob hormone. molecular pathology: MP, 54(5), 311-316. https://doi.org/10.1136/mp.54.5.311
- Rosenzweig SA (2020). Kev nce qib txuas ntxiv ntawm Insulin-zoo li Kev Loj Hlob Factor Signaling. F1000Res Tshawb, 9, F1000 Kws qhia ntawv Rev-205. https://doi.org/10.12688/f1000research.22198.1
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 is a prominent growth factor which conducts many of the growth-promoting effects of growth hormone (GH) through GH's stimulation of IGF-1 release from the liver.1. IGF-1 signalling promotes growth and spread of cancer and drugs have been developed to target the IGF-1 receptor (IGF1R) to reduce IGF-1 signalling, although ineffective due to resistance to the drugs being developed in patients2. IGF-1 is designated to be a risk factor for prostate cancer and high serum levels of IGF-1 are associated with a variety of different cancers){kind=link}