Hypertrophic Effect of Endurance Exercise and the Potential Mechanisms

Endurance, lossis "aerobic" ce, feem ntau pom tias yog mob plawv ib ce muaj zog thiab tsis yog feem ntau txuam nrog skeletal leeg hypertrophy. Endurance ce yog txhais raws li exerting ib tug tsawg-siv load rau ib tug ntev lub sij hawm ntawm lub sij hawm, xws li cov nyhuv ntawm jogging ntawm lub calf cov nqaij ntshiv tab sis kuj encompasses siv lub teeb hnyav nyob rau hauv tsis kam. ib ce muaj zog. Txawm li cas los xij, ib txoj kev tshawb fawb tsis ntev los no, uas qhia txog cov kab mob pob txha hauv pob txha hauv cov nas mob ntshav qab zib, tau tshawb pom cov nyhuv hypertrophic ntawm kev tawm dag zog (qhov no, treadmill khiav ntawm cov leeg nqaij gastrocnemius), txawm tias cov nas tsis muaj ntshav qab zib. Nws kuj tseem qhia txog ob qhov tshwj xeeb ntawm cov leeg nqaij pob txha, Kinesin Family Member 5B (KIF5B) thiab Kev Loj Hlob Associated Protein 43 (GAP-43), lawv qhov kev ua haujlwm tsis zoo hauv ntshav qab zib thiab yuav ua li cas kev tawm dag zog txhawb nqa pob txha pob txha hypertrophy los ntawm cov txheej txheem protein tshwj xeeb.

Hauv txoj kev tshawb no, 52 tus txiv neej nas tau muab faib ua 4 pawg: kev tswj hwm (kev noj qab haus huv, tsis muaj ntshav qab zib), kev tiv thaiv kev tiv thaiv, kev mob ntshav qab zib, endurance-krained diabetics. K1F5B, GAP-43 thiab PAX7 (cov leeg nqaij satellite uas yog lub luag haujlwm rau cov leeg nqaij rov qab los ib ce muaj zog-induced nqaij puas²) abundance, as well as gastrocnemius cross-sectional area (CSA) raug xam.

cov ntshav qab zib pab pawg neeg tsis tau txais kev kawm tau qis dua gastrocnemius CSA piv rau pawg tswj tsis tau kawm, thiab yuav luag ib nrab ntawm cov leeg nqaij nuclei (myonuclei) thiab yuav luag ib feem peb ntawm satellite cell (PAX7) abundance ntawm pawg tswj untrained. Qhov no qhia txog cov pathologies loj hauv cov leeg pob txha ntawm cov ntshav qab zib. Txawm li cas los xij, cov pab pawg kws kho mob ntshav qab zib tau muaj qhov zoo dua tsis zoo ntawm nqaij kev noj qab haus huv, thiab muaj yuav luag tib yam CSA, myonuclei thiab PAX7 abundance raws li untrained tswj, qhia txog qhov tseem ceeb hypertrophic nyhuv ntawm endurance-kev cob qhia ib leeg thiab lub peev xwm nyob rau hauv kev kho mob tiv thaiv cov ntshav qab zib-vim cov leeg pathologies. Cov kev tswj hwm kev noj qab haus huv tau txais txiaj ntsig zoo rau cov leeg nqaij tsis zoo rau txhua pawg, nrog rau CSA siab dua, thiab myonuclei thiab PAX7 ntau.

KIF5B protein tau zoo sib xws nrog myonuclei naj npawb thiab cov leeg CSA. KIF5B tau raug txo qis hauv cov ntshav qab zib thiab kev ua siab ntev-kev cob qhia ua kom cov protein ntau ntxiv. KIF5B ntseeg tau tias yog lub luag haujlwm rau qhov chaw ntawm myonuclei hauv cov leeg (cov leeg muaj ntau lub nuclei tsis zoo li feem ntau lwm hom cell thiab myonuclei tshiab tuaj yeem tsim txawm tias cov neeg laus los ntawm txoj kev xws li tsis kam ib ce muaj zog³). Tsis tas li ntawd, GAP-43 protein kuj tseem muaj txiaj ntsig zoo sib xws nrog myonuclei tus lej thiab cov leeg CSA. GAP-43 kuj tseem raug txo qis hauv mob ntshav qab zib thiab endurance-kev cob qhia ho nce cov protein. GAP-43 ntseeg tau tias yuav koom nrog kev tswj hwm calcium. Yog li ntawd, kev txhim kho ntawm ob qho tib si cov proteins hauv zos hauv cov nqaij leeg hauv gastrocnemius los ntawm kev ua siab ntev-kev cob qhia ntawm cov leeg zoo li muab cov nyhuv hypertrophic, muaj feem cuam tshuam los ntawm cov txheej txheem protein thiab qhov kev tshawb fawb no kuj tseem ua rau muaj peev xwm ua rau cov leeg pob txha tsis ua haujlwm xws li atrophy pom hauv cov neeg mob ntshav qab zib. .

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References:  

1. Rahmati, M., Taherabadi, SJ 2021. Cov teebmeem ntawm kev tawm dag zog ntawm Kinesin thiab GAP-43 qhia hauv cov leeg nqaij pob txha ntawm STZ-induced ntshav qab zib nas. Sci Rep 11, 9535. https://doi.org/10.1038/s41598-021-89106-6 

2. Sambasivan R, Yao R, et al 2011. Pax7-expressing satellite cells yog qhov tseem ceeb rau cov neeg laus cov leeg pob txha rov tsim dua tshiab. Kev loj hlob. 2011 Sep; 138(17):3647-56. doi: https://doi.org/10.1242/dev.067587 . Nyob rau hauv: Development. 2011 Nov; 138(19):4333. PIB: 21828093. 

3. Bruusgaard JC, Johansen IB, thiab al 2010. Myonuclei tau txais los ntawm kev tawm dag zog ntau dhau ua ntej hypertrophy thiab tsis poob ntawm kev sib tw. Cov txheej txheem ntawm National Academy of Sciences Lub Yim Hli 2010, 107 (34) 15111-15116; DOI: https://doi.org/10.1073/pnas.0913935107  

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