Dab tsi ua rau mob hnyav Covid-19 cov tsos mob? Cov ntaub ntawv pov thawj qhia tias qhov ua tsis tiav ntawm hom I Interferon tiv thaiv kab mob thiab autoantibodies tiv thaiv hom I Interferon yog qhov ua rau muaj teeb meem loj. Covid-19. Cov yuam kev no tuaj yeem txheeb xyuas tau siv tag nrho genome sequencing, yog li ua rau kom raug cais tawm thiab kho.
Ib daim ntawv tsis ntev los no cuam tshuam lub teeb ntawm kev ua rau muaj kev cuam tshuam loj heev Covid-19 mob ntsws o.
Ntau tshaj 98% ntawm cov neeg muaj tus kab mob no tsis muaj cov tsos mob ntawm tus kab mob los yog mob me kab mob. Tsawg dua 2% ntawm cov neeg muaj tus kab mob no tshwm sim mob ntsws loj 1-2 lub lis piam tom qab kis kab mob thiab yuav tsum tau mus pw hauv tsev kho mob vim mob ua pa nyuaj thiab / lossis lub cev tsis ua haujlwm. Tsawg dua 0.01% ntawm cov neeg muaj tus kab mob no mob hnyav heev zoo li tus kab mob Kawasaki (KD).
Cov hnub nyoog Advanced tau pom tias muaj kev pheej hmoo loj rau txoj sia Covid-19 mob ntsws o. Feem ntau ntawm cov neeg uas yuav tsum tau mus pw hauv tsev kho mob yog ntau dua 67 xyoo - cov kab mob tseem ceeb tau pom tias muaj 3.5 npaug ntawm cov neeg muaj hnub nyoog tshaj 75 xyoo dua li cov neeg muaj hnub nyoog qis dua 45 xyoo. Cov txiv neej muaj kev pheej hmoo siab ntawm kev tsim cov tsos mob hnyav.
Cov neeg uas muaj comorbidities zoo li kub siab, mob ntshav qab zib, kab mob plawv, kab mob pulmonary ntev, thiab rog rog muaj kev pheej hmoo siab ntawm kev tsim cov tsos mob hnyav.
Qee cov genotypes tau ua rau muaj qhov mob hnyav rau COVID-19 phenotype. Inborn yuam kev ntawm kev tiv thaiv interferon ua lub luag haujlwm tseem ceeb hauv kev txhim kho cov tsos mob hnyav. Cov neeg mob uas muaj kev hloov pauv tsis zoo ntawm 13 loci (tus lej ntawd rau kev tiv thaiv kab mob sib txuas nrog cov proteins) muaj qhov cuam tshuam tsis zoo. Cov kev ua yuam kev no cuam tshuam rau hom I Interferon kev tiv thaiv yog li ua rau mob ntau dhau thiab cov tsos mob tseem ceeb ntawm COVID-19. Tsis tas li ntawd, neutralizing autoantibodies tiv thaiv hom I interferons muaj nyob hauv tsawg kawg 10% ntawm cov neeg mob uas muaj mob hnyav rau lub neej.
Daim ntawv no xaus lus tias kev yug me nyuam tsis raug ntawm hom I Interferon tiv thaiv kab mob thiab autoantibodies tawm tsam hom I Interferon yog qhov ua rau muaj qhov tseem ceeb ntawm COVID-19.
Tej zaum kev txheeb xyuas cov neeg uas muaj cov genotypes yuav mus ntev hauv kev tiv thaiv thiab kho qhov tshwm sim ntawm tus kab mob hnyav. Tag nrho cov genome sequencing ntawm tib neeg tuaj yeem siv los txheeb xyuas cov neeg mob tsis zoo uas ua rau lawv raug cais tawm thiab kho kom raug.
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Qhov (s):
Zhang Q., Bastard P., Bolze A., et al., 2020. Txoj Kev Ua Phem Rau Tus Kab Mob Khaus Viv-19 (COVID-1): Kev cuam tshuam tsis zoo ntawm cov kab mob cuam tshuam rau kev mob ntau dhau. Med. Nqe 1, Nqe 18, 2020 Lub Kaum Ob Hlis 14, Nplooj 20-XNUMX. DOI: https://doi.org/10.1016/j.medj.2020.12.001
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Lus raug kaw.