Daim ntawv tshaj tawm ua ntej ntawm kev tshawb pom los ntawm kev sim tshuaj NCT02735707 tau tshaj tawm hauv kev luam tawm ua ntej qhia tias Tocilizumab thiab Sarilumab, interleukin-6 receptor antagonists tau txais txiaj ntsig zoo hauv kev kho mob hnyav rau cov neeg mob COVID-19 thiab txhim kho kev ciaj sia..
Hnyav heev Cov neeg mob COVID-19 uas tau txais kev saib xyuas mob hnyav tau teb zoo rau kev kho mob nrog IL-6 receptor antagonists, tocilizumab thiab sarilumab. Lub tsev kho mob lub neej no yog 28.0% rau tocilizumab, 22.2% rau sarilumab thiab 35.8% rau kev tswj lub ntsiab lus ciaj sia taus txhim kho txhawb kev ua tau zoo ntawm cov tshuaj repurposed. (1)
Cov tshuaj tocilizumab (ib tug humanized monoclonal antibody tiv thaiv IL-6 receptor) thiab sarilumab (ib tug tib neeg monoclonal tshuaj tiv thaiv tawm tsam IL-6 receptor) feem ntau yog siv los ua cov tshuaj tiv thaiv kab mob hauv kev kho mob rheumatoid mob caj dab.
Hauv kev nyab xeeb tam sim no ntawm Covid-19 Kev kis thoob qhov txhia chaw thaum muaj neeg tuag thiab kis tus kab mob ntau, nws yog qhov nthuav heev uas yuav tsum nco ntsoov tias ob cov tshuaj siv rov qab no tau txo qis COVID-19 cov neeg mob nyob hauv cov tsev kho mob hnyav hauv tsev kho mob thiab txo cov neeg tuag los ntawm ib lub hlis twg. Qhov no txhais tau tias tsawg dua kev tuag thiab nyob luv luv hauv kev saib xyuas tseem ceeb, yog li khaws cia cov tsev kho mob muaj peev xwm tiv thaiv tus kabmob kis.
Qhov kev sim tshuaj no tau txais nyiaj los ntawm EU uas txhawb nqa REMAP-CAP los ntawm Platform rau European Kev Npaj Tawm Tsam Tawm Tsam (Re-) Kev Tawm Tsam Tawm Tsam Tawm Tsam (PREPARE). Kev txhawb nqa ntxiv los ntawm qhov cuam tshuam nrog Rapid European SARS-CoV-2 Emergency Research response (RECOVER) project (2).
***
Qhov chaw:
- REMAP-CAP Cov Kws Tshawb Fawb, Gordon AC., 2020. Interleukin-6 Receptor Antagonists hauv Cov Neeg Mob hnyav nrog Covid-19 - Qhia ua ntej. Preprint: MedRxiv. Tshaj tawm Lub Ib Hlis 07, 2021. DOI: https://doi.org/10.1101/2021.01.07.21249390
- European Commission, 2021. Xov xwm - EU tau txais nyiaj los ntawm kev sim tshuaj ntsuam xyuas pom cov kev kho tshiab kom ua tau zoo tiv thaiv COVID-19. Luam tawm Lub Ib Hlis 8, 2021. Muaj online https://ec.europa.eu/info/news/eu-funded-clinical-trial-finds-new-treatments-be-effective-against-covid-19-2021-jan-08_en&pk_campaign=rtd_news
- Clinical Trial NCT02735707: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia (REMAP-CAP) Muaj nyob online ntawm https://clinicaltrials.gov/ct2/show/NCT02735707?term=NCT02735707&cond=Covid19&draw=2&rank=1#contacts
***
Lus raug kaw.