Lambda Variant (C.37) of SARS-CoV2 Has Higher Infectivity and Immune Escape

Lub Lambda variant ( kab C.37) ntawm SARS-Cov-2 tau txheeb xyuas nyob rau yav qab teb Brazil. Qhov no tau pom tias muaj kev sib kis loj heev hauv qee qhov South America. Nyob rau hauv qhov kev pom ntawm tus nqi siab ntawm kev sib kis thoob plaws South America, qhov sib txawv no tau tshaj tawm tias yog qhov sib txawv ntawm kev txaus siab lossis qhov sib txawv raws li kev tshawb nrhiav (VOI) los ntawm WHO thaum Lub Rau Hli 15, 2021.^1,2  

Lambda variant muaj kev hloov pauv tseem ceeb hauv cov protein ntau. Qhov cuam tshuam ntawm kev hloov pauv ntawm kev kis kab mob thiab kev tiv thaiv kab mob los ntawm cov tshuaj tiv thaiv neutralizing tsis paub. Ib txoj kev tshawb fawb tsis ntev los no qhia tau hais tias kev hloov pauv hauv cov protein ntau ntawm Lambda variant ua rau muaj kev sib kis thiab tiv thaiv kev tiv thaiv los ntawm cov tshuaj tiv thaiv tsis zoo.³ Cov ntaub ntawv no ua rau cov kev tshawb fawb genomic ntawm cov mutants thiab kev tshawb fawb txog kev tiv thaiv kab mob ib qho tseem ceeb suav nrog kev kawm yog tias cov tshuaj tiv thaiv uas twb muaj lawm muaj txiaj ntsig zoo rau cov kev hloov pauv.  

Raws li qhov kev tshawb pom no, nws yog ib txwm xav tsis thoob yog tias cov tshuaj tiv thaiv tam sim no tiv thaiv COVID-19 tseem yuav ua haujlwm zoo rau cov kev hloov pauv tshiab xws li Lambda uas muaj qhov tseem ceeb. change nyob rau hauv lub spike protein. Nws tau sib cav tias cov tshuaj tiv thaiv uas twb muaj lawm yuav tsum muaj tsawg kawg yog qee qhov kev tiv thaiv tawm tsam cov tshuaj tiv thaiv tshiab vim tias cov tshuaj tiv thaiv ua rau muaj kev tiv thaiv kab mob dav dav hauv cov kab mob ntawm cov hlwb thiab cov tshuaj tiv thaiv. Yog li ntawd, cov tshuaj tiv thaiv yuav tsis ua haujlwm tsis zoo vim yog kev hloov pauv hauv cov protein ntau. Tsis tas li ntawd, ib txwm muaj qhov ua tau zoo ntawm cov tshuaj tiv thaiv antigenic los npog cov kev hloov pauv rau kev tiv thaiv kev sib txawv.⁴ 

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References:  

1. Wink PL, Volpato FCZ, et al 2021. First identification of SARS-CoV-2 Lambda (C.37) variant in Southern Brazil. Tshaj tawm rau lub Rau Hli 23, 2021. doi: https://doi.org/10.1101/2021.06.21.21259241    

2. Romero PE, Dávila-Barclay A, et al 2021.The Emergence of SARS-CoV-2 Variant Lambda (C.37) in South America. Tshaj tawm Lub Xya Hli 03, 2021. doi: https://doi.org/10.1101/2021.06.26.21259487  

3. Acevedo ML, Alonso-Palomares L, et al 2021.Infectivity and immune escape of the new SARS-CoV-2 variant of interest Lambda. Tshaj tawm Lub Xya Hli 01, 2021. doi: https://doi.org/10.1101/2021.06.28.21259673  

4. WHO, 2021. Qhov cuam tshuam ntawm tus kab mob variants ntawm cov tshuaj tiv thaiv COVID-19. Muaj nyob online ntawm https://www.who.int/news-room/feature-stories/detail/the-effects-of-virus-variants-on-covid-19-vaccines?gclid=EAIaIQobChMIyvqw5_zQ8QIVCLqWCh2SkQeYEAAYASAAEgLv__D_BwE Tau txais los ntawm 07 Lub Xya hli ntuj 2021.  

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