Gene variant uas tiv thaiv COVID-19 hnyav

A gene variant ntawm OAS1 tau cuam tshuam txog kev txo qis kev pheej hmoo ntawm COVID-19 hnyav kab mob. Qhov no tau lees paub tsim cov tshuaj / tshuaj uas tuaj yeem nce qib ntawm OAS1 enzyme, yog li txo qhov hnyav ntawm COVID-19.

Hnub nyoog Advanced thiab comorbidities paub tias yog ib qho kev pheej hmoo siab rau COVID-19. Muaj ntau qhov kev tshawb fawb qhia tias kev tshuaj ntsuam genetic predisposes qee tus neeg mus rau cov tsos mob hnyav ntawm COVID-19, thaum lwm tus yuav luag tiv thaiv tus kab mob.¹.   

Thaum tshawb xyuas seb puas muaj cov kab mob sib kis cuam tshuam rau kev raug mob thiab hnyav rau COVID-19, cov kws tshawb fawb pom tias muaj kev sib koom ua ke ntawm OAS enzyme ntau ntxiv nrog txo qis COVID-19 qhov hnyav lossis tuag. OAS genes encode enzymes uas yog induced los ntawm interferons thiab qhib latent RNase L, ua rau degradation ntawm intracellular ob-stranded RNA, raws li tau zoo raws li antiviral mechanism. Lub OAS1/2/3 locus ntawm chromosome 12 (12q24.13), ntawm Neanderthal keeb kwm qhia 23% txo qis kev pheej hmoo ntawm cov neeg mob ua mob hnyav nrog COVID-19.². Thaum qee qhov kev tshawb fawb cuam tshuam txog qib OAS1 nce ntxiv nrog txo kev pheej hmoo rau COVID-19, lwm cov kev tshawb fawb cuam tshuam txog kev nce qib OAS3 kom cuam tshuam nrog txo kev pheej hmoo. Vim tias muaj ntau yam kab mob sib txawv hauv qhov chaw, kev txheeb xyuas qhov txawv ntawm lub luag haujlwm yog qhov tseem ceeb rau kev tsim tshuaj rau cov neeg ua haujlwm uas nce qib OAS. 

Hauv kev soj ntsuam meta tsis ntev los no ntawm OAS cheeb tsam ntawm European poj koob yawm txwv uas nthuav dav 75Kb cheeb tsam harboring OAS1, 2 thiab 3 noob, cov neeg tshawb nrhiav pom qhov sib txawv, rs10774671, uas sawv cev ntev dua, 60% ntau dua daim ntawv ntawm OAS1 enzyme.². Qhov kev sib txawv no kuj tau pom nyob rau hauv cov tib neeg nrog poj koob yawm txwv African qhia tias cov tib neeg ntawm African caj ces muaj kev tiv thaiv tib yam li cov poj koob yawm txwv nyob sab Europe. Qhov sib txawv ntev ntawm cov protein tau pom tias muaj txiaj ntsig zoo hauv kev muab kev tiv thaiv SARS-CoV-2. Qhov kev tshawb fawb tsis ntev los no tau pom tias qhov sib txawv ntawm qhov sib txawv no (rs10774671) ntawm OAS1 yuav yog lub luag haujlwm rau kev koom tes nrog txo qis COVID-19 qhov hnyav.²

Raws li cov kev tshawb fawb no, cov neeg sawv cev uas nce qib OAS1, tau pom zoo kom ua qhov tseem ceeb rau kev txhim kho tshuaj³. 

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reference:  

1. Prasad U 2021. Cov noob caj noob ces ntawm COVID-19: Vim li cas Qee Cov Neeg Muaj Cov tsos mob hnyav. Kev tshawb fawb European. Tshaj tawm 6 Lub Ob Hlis 2021. Muaj nyob ntawm https://www.scientificeuropean.co.uk/covid-19/genetics-of-covid-19-why-some-people-develop-severe-symptoms/  
2. Huffman, JE, Butler-Laporte, G., Khan, A. et al. Ntau haiv neeg nplua nuj daim ntawv qhia cuam tshuam rau OAS1 splicing hauv kev pheej hmoo ntawm COVID-19 hnyav. Nat Genet (2022). Published: 13 January 2022. DOI: https://doi.org/10.1038/s41588-021-00996-8 
3. Zhou, S., Butler-Laporte, G., Nakanishi, T. et al. Ib qho Neanderthal OAS1 isoform tiv thaiv cov tib neeg ntawm cov poj koob yawm txwv nyob sab Europe tiv thaiv COVID-19 kev raug mob thiab hnyav. Nat Med 27, 659–667 (2021). Published: 25 Lub Ob Hlis 2021.DOI: https://doi.org/10.1038/s41591-021-01281-1 

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