Kev tiv thaiv tus kab mob COVID-19 tau pom nyob rau hauv cov neeg ua haujlwm saib xyuas kev noj qab haus huv thiab tau raug ntaus nqi los ntawm kev muaj lub cim xeeb T hlwb uas tsom rau RNA polymerase hauv RTC (replication transcription complex), yog li tiv thaiv kab mob. Qhov no ua rau RNA polymerase lub hom phiaj tseem ceeb rau kev txhaj tshuaj tiv thaiv kab mob pan-coronavirus uas yuav muaj txiaj ntsig tiv thaiv SARS-CoV-2 thiab nws lwm yam kev txhawj xeeb (VoC's), tab sis kuj tawm tsam tsev neeg ntawm Cov khaus laus nas vais lav feem ntau.
Covid-19 kab mob ntsws tam sim no yuav luag 2 xyoos thiab tau ua rau muaj kev puas tsuaj hauv ntiaj teb los ntawm kev cuam tshuam kev lag luam hauv ntiaj teb thiab txwv txoj kev ua neej nyob. Ntau lab tus neeg tau tuag thiab ntau ntxiv tau kis tus kab mob ua rau muaj kev mob hnyav heev. Txawm li cas los xij, muaj cov xwm txheej uas tib neeg tau tshem tawm tus kab mob los ntawm lub kaw lus sai heev uas lawv tsis tau kuaj pom qhov zoo. tus kab mob no los yog tsim cov tshuaj tiv thaiv tiv thaiv nws. Qhov kev tiv thaiv no tau raug ntaus nqi rau lub nco T hlwb-tejzaum nws yog cov uas tsim tom qab raug tus tib neeg lub cev rau xws li kab mob.
Hauv kev tshawb fawb tsis ntev los no luam tawm hauv Xwm los ntawm Swalding li al., kuaj ntshav los ntawm 60 tus neeg ua haujlwm saib xyuas kev noj qab haus huv, uas muaj kev pheej hmoo siab ntawm kev loj hlob. Covid-19 vim lawv raug, raug tshuaj xyuas thiab pom tias tsis zoo rau cov tus kab mob no thiab rau cov tshuaj tiv thaiv kab mob virus1 ua. Nws yog qhov kev xav tias lub cim xeeb ua ntej T-hlwb, nrog rau kev tiv thaiv kev tiv thaiv tiv thaiv SARS-CoV-2, nthuav dav hauv vivo los muab kev tshem tawm sai sai, yog li tshem tawm kev kis kab mob. Cov T hlwb no yog qhia tawm tsam cov RNA polymerase nyob rau hauv RTC (replication transcription complex), es tsis yog lwm yam qauv protein ntawm lub tus kab mob no. Cov cim xeeb T hlwb no tuaj yeem tsim tawm hauv cov neeg ua haujlwm saib xyuas kev noj qab haus huv los ntawm kev raug rau lwm yam ua pa lossis cuam tshuam txog corona kab mob, txawm tias tsis muaj pov thawj ncaj qha ntawm tib yam. Nws kuj tseem muaj peev xwm hais tias muaj lwm yam kev cuam tshuam ib puag ncig uas coj mus rau tiam ntawm cov T hlwb. Tsis tas li ntawd, cov tib neeg tsis zoo no kuj tau pom qhov nce hauv IFI27, ib qho protein qhia tias tsis muaj tus kab mob SARS-CoV-2. IFI27 yog ib qho interferon alpha inducible protein uas yog overexpressed thaum raug rau ntau yam ua pa. kab mob, including SARS-CoV-2. Qhov no kuj tseem yog lub luag haujlwm rau kev tshem tawm cov kab mob hauv tib neeg, ua ntej raug rau lwm yam ua pa kab mob, thiab ces kis tus kab mob SARS-CoV-2.
Qhov tseeb tias lub cim xeeb T hlwb raug coj tawm tsam cov RNA polymerase (ua qhov tshwj xeeb tshaj plaws ntawm tib neeg mob hlwb uas ua rau mob khaub thuas thiab SARS-CoV-2), ua rau cov enzyme no yog lub hom phiaj tseem ceeb los tsim lub lauj kaub-mob hlwb Cov tshuaj tiv thaiv uas yuav tsis yog tsuas yog qhia tawm tsam SARS-CoV-2 thiab nws lwm yam kev txhawj xeeb (VoC's) uas tau hloov zuj zus los ntawm kev hloov pauv ntawm cov protein ntau uas ua rau muaj kab mob hnyav dua, tab sis kuj tawm tsam tsev neeg ntawm Coronaviruses feem ntau.
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Tau qhov twg los:
Swadling, L., Diniz, MO, Schmidt, NM et al. Pre-existing polymerase-specific T cells nthuav nyob rau hauv abortive seronegative SARS-CoV-2. Xwm (2021). https://doi.org/10.1038/s41586-021-04186-8
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, thereby preventing infection. This makes RNA polymerase an important target for making a pan-coronavirus vaccine that will be effective against SARS-CoV-2 and its other variants of concern (VoC’s), but also against the family of Coronaviruses in general.){kind=link}