Oxford/AstraZeneca COVID-19 Vaccine (ChAdOx1 nCoV-2019) Pom Zoo thiab Pom Zoo

Cov ntaub ntawv ib ntus los ntawm theem III kev sim tshuaj ntawm Oxford University / AstraZeneca Cov Tshuaj Tiv Thaiv-19 qhia pom tias cov tshuaj tiv thaiv muaj txiaj ntsig zoo los tiv thaiv COVID-19 tshwm sim vim tus kab mob SARS-CoV-2 thiab muaj kev tiv thaiv qib siab tiv thaiv kab mob. 

Kev sim theem III tau sim ob hom tshuaj sib txawv. Qhov kev ua tau zoo dua qub tau siv halved thawj koob thiab koob thib ob. Kev soj ntsuam ib ntus qhia tau hais tias kev ua tau zoo yog 90% hauv kev ua tau zoo dua qub thiab 62% hauv lwm qhov kev tswj hwm nrog kev ua haujlwm tag nrho ntawm 70.4% thaum cov ntaub ntawv los ntawm ob txoj kev siv tshuaj ua ke. Tsis tas li ntawd, los ntawm cov neeg tau txais cov tshuaj tiv thaiv, tsis muaj ib qho kev nce mus rau qhov mob hnyav uas yuav tsum tau mus pw hauv tsev kho mob ⁽¹⁾.  

Raws li kev soj ntsuam ntawm cov ntaub ntawv ib ntus, Tshuaj thiab Cov Khoom Siv Khomob Tswj Xyuas Kev Noj Qab Haus Huv (MHRA), lub koom haum tswj hwm tau xaus lus tias koob tshuaj tiv thaiv tau ntsib nws cov qauv kev nyab xeeb, zoo thiab ua tau zoo. Tom qab ntawd tsoomfwv tau lees txais cov lus pom zoo ntawm MHRA thiab tau tso cai pom zoo ⁽²⁾.  

Qhov tseem ceeb, tsis zoo li kev pom zoo ua ntej 'COVID-19 mRNA tshuaj tiv thaiv', cov tshuaj tiv thaiv no muaj qhov zoo sib xws vim tias tuaj yeem khaws cia ntawm lub tub yees kub li 2-8 ° C thiab tuaj yeem muab faib rau kev tswj hwm ntawm cov chaw kho mob uas siv cov khoom thauj uas twb muaj lawm uas ua rau nws muaj peev xwm txhaj tshuaj tiv thaiv kab mob. hauv kev tawm tsam kev sib kis thoob ntiaj teb. Txawm li cas los xij, cov tshuaj tiv thaiv mRNA muaj peev xwm dav dua hauv kev kho mob thiab kis kab mob hauv nruab nrab thiab ntev. ⁽³⁾.   

Oxford / AstraZeneca Tshuaj tiv thaiv kab mob covid-19 siv cov tsis muaj zog thiab hloov pauv hloov pauv ntawm cov kab mob khaub thuas sib kis adenovirus (ib tus kab mob DNA) ua vector rau kev nthuav tawm cov kab mob protein ntawm tus kab mob tshiab coronavirus nCoV-2019 hauv tib neeg lub cev. Cov tshuaj tiv thaiv kab mob kis tau ua raws li antigen rau kev loj hlob ntawm kev tiv thaiv kab mob. Tus kab mob adenovirus siv yog replication incompetent lub ntsiab lus nws yuav replicate nyob rau hauv tib neeg lub cev tab sis raws li vector nws muab lub cib fim rau kev txhais lus ntawm incorporated gene encoding Spike protein (S) ntawm tshiab coronavirus. ^(1,4).  

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Qhov chaw (s):  

1. Oxford University 2020. Xov Xwm - Oxford University kev ua txhaum ntawm cov tshuaj tiv thaiv COVID-19 thoob ntiaj teb. Luam tawm 30 Kaum Ob Hlis 2020. Muaj online ntawm https://www.ox.ac.uk/news/2020-11-23-oxford-university-breakthrough-global-covid-19-vaccine Tau txais los ntawm 30 Lub Kaum Ob Hlis 2020.  

2. MHRA, 2020. Tshuaj thiab cov khoom kho mob raws cai. Kev tshaj tawm - Oxford University / AstraZeneca tshuaj tiv thaiv tau tso cai los ntawm UK cov tshuaj tswj hwm. Luam tawm 30 Kaum Ob Hlis 2020. Muaj online ntawm https://www.gov.uk/government/news/oxford-universityastrazeneca-vaccine-authorised-by-uk-medicines-regulator Tau txais los ntawm 30 Lub Kaum Ob Hlis 2020. 

3. Prasad U., 2020. COVID-19 mRNA Vaccine: Ib Qhov Tseem Ceeb hauv Kev Tshawb Fawb thiab Kev Hloov Pauv Hauv Tshuaj. Kev tshawb fawb European. Muaj nyob online ntawm https://www.scientificeuropean.co.uk/medicine/covid-19-mrna-vaccine-a-milestone-in-science-and-a-game-changer-in-medicine/  

4. Feng, L., Wang, Q., Shan, C. et al. 2020. Ib qho tshuaj tiv thaiv kab mob adenovirus-vectored COVID-19 muab kev tiv thaiv los ntawm SARS-COV-2 kev sib tw hauv rhesus macaques. Published: 21 August 2020. Nature Communications 11, 4207. DOI: https://doi.org/10.1038/s41467-020-18077-5  

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