Tom qab kev soj ntsuam thiab kev pom zoo los ntawm European Medicines Agency (EMA), WHO tau tshaj tawm cov npe siv thaum muaj xwm ceev (EUL) rau Nuvaxovid rau 21 Lub Kaum Ob Hlis 2021. Ua ntej ntawm 17 Kaum Ob Hlis 2021, lub LEEJ TWG tau tshaj tawm cov npe siv thaum muaj xwm ceev (EUL) rau Covovax.
Covovax thiab Nuvaxoid yog li dhau los ua 9th thiab 10th Covid-19 tshuaj tiv thaiv hauv WHO cov npe siv thaum muaj xwm ceev.
Ob Nuvaxovid & Covovax tshuaj tiv thaiv yog protein subunit tshuaj tiv thaiv, thiab siv nanoparticles. Cov no yog tsim los siv cov tshuab nanoparticle recombinant los tsim cov tshuaj tiv thaiv los ntawm tus kab mob coronavirus spike (S) protein thiab muaj patented saponin-raws li Matrix-M adjuvant los txhim kho lub cev tiv thaiv kab mob thiab txhawb cov qib siab ntawm neutralizing antibodies.
Ob qho no tshuaj tiv thaiv muaj purified protein antigen uas tsis tuaj yeem rov ua dua, thiab tsis tuaj yeem ua rau tus kab mob COVID-19.
Nuvaxovid & Covovax xav tau ob koob tshuaj thiab ruaj khov ntawm 2 mus rau 8 ° C txias txias.
Nuvaxovid yog tsim los ntawm Novavax, Inc., ib lub tuam txhab American biotechnology nyob hauv Maryland. Nws yog lub hauv paus khoom tsim rau Covovax.
Covovax tau tsim los ntawm Novavax thiab Coalition for Epidemic Preparedness Innovations (CEPI) thiab yog tsim los ntawm Serum Institute of India (SII) raws li daim ntawv tso cai los ntawm Novavax. Qhov no yog ib feem ntawm COVAX cov ntaub ntawv pov thawj, muab kev txhawb nqa ntau heev rau kev siv zog txuas ntxiv mus txhaj tshuaj tiv thaiv tib neeg ntxiv hauv cov chaw muaj kev txwv.
Covovax thiab Nuvaxoid zoo ib yam li Cuba's Soberana 02 thiab Abdala hauv kev ua cov tshuaj tiv thaiv kab mob tiv thaiv COVID-19 tab sis Cuba's tshuaj tiv thaiv tshwj xeeb yog siv RBD (receptor binding domain) thaj tsam ntawm cov kab mob sib kis kab mob, lub luag haujlwm rau kev nkag mus rau tus kab mob rau hauv tib neeg lub hlwb thaum Nuvaxovid & Covovax lub hom phiaj tus kab mob coronavirus spike (S) protein.
Zoo li Cuba tshuaj tiv thaiv, Nuvaxovid & Covovax kuj muaj qhov zoo ntawm kev ruaj khov ntawm 2-8 ° C thiab tuaj yeem tsim tau yooj yim los tsim cov tshuaj tiv thaiv tshiab tiv thaiv kab mob sib hloov.
Cov lus hais saum toj no cov protein-raws li COVID-19 tshuaj tiv thaiv txawv qhov txawv ntawm COVID-19 uas twb muaj lawm tshuaj tiv thaiv tam sim no siv. Thaum cov tshuaj tiv thaiv mRNA (tsim los ntawm Pfizer / BioNTech thiab Moderna) muaj cov lus qhia txog cov kab mob protein antigen hauv tib neeg lub hlwb, adenovirus vector-based tshuaj tiv thaiv (xws li Oxford/AstraZeneca's ChAdOx1 nCoV-2019 thiab Janssen's) siv genetically engineered adenovirus ua tus vector los nqa spike-protein gene ntawm tus kab mob tshiab coronavirus uas tau qhia hauv tib neeg lub hlwb uas ua raws li antigen rau kev tiv thaiv kab mob. Tsis tas li ntawd, cov tshuaj tiv thaiv mRNA yog tus nqi kim thiab muaj qhov teeb meem ntawm cov kab mob khaub thuas thaum cov tshuaj tiv thaiv kab mob vector-based adenovirus cuam tshuam rau qhov tsis tshua muaj tshwm sim ntawm cov ntshav txhaws.
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Qhov chaw:
- LEEJ TWG 2021. Xov Xwm - WHO teev 10 koob tshuaj tiv thaiv COVID-19 rau kev siv thaum muaj xwm txheej ceev: Nuvaxovid. Tshaj tawm Lub Kaum Ob Hlis 21, 2021, Muaj nyob online ntawm https://www.who.int/news/item/21-12-2021-who-lists-10th-covid-19-vaccine-for-emergency-use-nuvaxovid
- EMA 2021. Xov Xwm - EMA pom zoo Nuvaxovid rau kev tso cai hauv EU, Tshaj tawm 20/12/2021. Muaj nyob online ntawm https://www.ema.europa.eu/en/news/ema-recommends-nuvaxovid-authorisation-eu
- WHO 2021. Xov Xwm - WHO teev 9 koob tshuaj tiv thaiv COVID-19 rau kev siv thaum muaj xwm txheej ceev nrog lub hom phiaj txhawm rau txhawm rau txhawm rau txhawm rau txhaj tshuaj tiv thaiv hauv cov tebchaws tau nyiaj tsawg. Tshaj tawm rau lub Kaum Ob Hlis 17, 2021. Muaj nyob online ntawm https://www.who.int/news/item/17-12-2021-who-lists-9th-covid-19-vaccine-for-emergency-use-with-aim-to-increase-access-to-vaccination-in-lower-income-countries
- Tian, JH., Patel, N., Haupt, R. et al. SARS-CoV-2 spike glycoprotein tshuaj tiv thaiv tus neeg sib tw NVX-CoV2373 immunogenicity hauv baboons thiab kev tiv thaiv hauv nas. Nat Commun 12, 372 (2021). https://doi.org/10.1038/s41467-020-20653-8
- Khan S., thiab Dhama K. 2021. Is Nrias teb lub luag haujlwm hauv COVID-19 tshuaj tiv thaiv kab mob sib kis. Phau ntawv Journal of Travel Medicine, Volume 28, Issue 7, October 2021, taab064, Published: 16 April 2021. DOI: https://doi.org/10.1093/jtm/taab064
- Soni R., 2021.Soberana 02 thiab Abdala: Ntiaj teb thawj Protein conjugate Tshuaj tiv thaiv tiv thaiv COVID-19. Kev tshawb fawb European. Tshaj tawm 30 Kaum Ib Hlis 2021. Muaj nyob online ntawm http://scientificeuropean.co.uk/covid-19/soberana-02-and-abdala-worlds-first-protein-conjugate-vaccines-against-covid-19/
- Prasad U. 2021. Hom tshuaj tiv thaiv COVID-19 hauv Vogue: Puas Muaj Ib Yam Tsis Txaus Siab? Kev tshawb fawb European. Tshaj tawm Lub Ib Hlis 20, 2021. Muaj nyob online ntawm http://scientificeuropean.co.uk/covid-19/types-of-covid-19-vaccine-in-vogue-could-there-be-something-amiss/
- Soni R. 2021. Yav tom ntej ntawm Adenovirus raws li cov tshuaj tiv thaiv COVID-19 (xws li Oxford AstraZeneca) nyob rau hauv lub teeb pom kev tsis ntev los no txog Ua rau muaj kev phiv tsis tshua muaj ntshav txhaws. Kev tshawb fawb European. Tshaj tawm Lub Kaum Ob Hlis 3, 2021. Muaj nyob online ntawm http://scientificeuropean.co.uk/covid-19/future-of-adenovirus-based-covid-19-vaccines-such-as-oxford-astrazeneca-in-light-of-recent-finding-about-cause-of-rare-side-effects-of-blood-clot/
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