Nitric Oxide (NO): Lub Riam Phom Tshiab Hauv Kev Tawm Tsam Tiv Thaiv COVID-19

Kev tshawb pom los ntawm tsis ntev los no tau xaus rau theem 2 kev sim tshuaj hauv Canada thiab UK qhia tias nitric oxide (NO) tuaj yeem pab tau zoo hauv kev tiv thaiv thiab kho Covid-19.

Nitric oxide NO, (tsis txhob totaub nrog nitrous oxide N₂O siv los ua tshuaj loog hauv chaw kho mob) tseem hu ua endothelium-derived relaxing factor (EDRF) yog ib qho kev paub txog kev siv tshuaj loog uas yog synthesized endogenously thiab ua lub luag haujlwm tseem ceeb hauv kev so ntawm cov leeg nqaij. ntshav cov hlab ntsha ua rau vasodilation thiab nce ntshav khiav. Nws feem ntau yog siv los ua prodrug Glyceryl trinitrate GTN los txo qhov mob hauv siab (angina). Sildenafil (Viagra) siv tib txoj kev nitric acid rau vasodilation.  

Lwm cov cuab yeej tshawb nrhiav tsawg dua ntawm nitric oxide (NO) yog nws cov tshuaj tiv thaiv kab mob tiv thaiv kab mob microbes suav nrog kab mob lub luag haujlwm rau cov kab mob ua pa xws li tsev kho mob tau mob ntsws. Nitric oxide kuj tau pom tias muaj cov tshuaj tiv thaiv kab mob tseem ceeb. Tsis muaj inhalation tau pom los txhim kho tus mob ntawm cov neeg mob cuam ​​tshuam los ntawm SARS.  

Txij li thaum SARS-CoV2 muaj feem cuam tshuam nrog SARS-CoV, nws tau xav tias TSIS muaj peev xwm tiv thaiv tau. SARS-CoV-2 zoo li ^1,2. Cov kev mob tsis zoo uas pom nyob rau hauv Covid-19 yog vim SARS-CoV2 ua rau nitric oxide (NO) ua haujlwm tsis zoo hauv cov hlwb thiab cov ntaub so ntswg ua rau txo qis endogenous NO qib thiab bioavailability. Yog li, txhim kho nitric oxide (NO) muaj nyob rau hauv exogenously los ntawm kev tsim nyog xws li nqus pa, tshuaj tsuag qhov ntswg, gargle, tso tshuaj thiab lwm yam yuav tsum pab cov neeg mob COVID-19.³.  

Tam sim no, ntau qhov kev sim tshuaj tau tab tom sim los ntsuas qhov ua tau zoo ntawm NO ua tus kws kho mob thiab tiv thaiv tus neeg saib xyuas kev tswj hwm COVID-19. Cov kev tshawb fawb tseem ceeb yog hauv qab no- 

Inhalation: Nitric Oxide Gas Inhalation Therapy rau Kev Kho Mob Me / Nruab Nrab COVID-19 (NoCovid): Qhov kev sim thib 2 no yog txhawb nqa los ntawm Massachusetts General Tsev Kho Mob thiab tab tom sim seb qhov nqus ntawm nitric oxide (NO) tiv thaiv kev loj hlob ntawm cov neeg mob uas muaj tus kab mob me me mus rau nruab nrab COVID-19.  Tsis Muaj Kev Tiv Thaiv Kab Mob Khaus Viv-19 (COVID-XNUMX) rau Cov Kws Kho Mob (NOpreventCOVID) yog lwm txoj kev tshawb fawb los ntawm Massachusetts General Tsev Kho Mob thiab tau tsim los sim seb puas muaj nitric oxide pa nqus pa tiv thaiv COVID-19 ntawm cov neeg ua haujlwm kho mob.  

Nasal Spray: Nitric Oxide Nasal Spray rau COVID-19 kho: Kev txhawb nqa los ntawm Ashford thiab St Peter's Hospitals NHS Foundation Trust, txoj kev tshawb no tsom mus kuaj seb puas muaj nitric oxide (NO) xa los ntawm cov tshuaj tsuag qhov ntswg kho cov tsos mob me me ntawm COVID-19.  

Tso cov kev daws teeb meem: Nitric Oxide tso cov kev daws teeb meem los tiv thaiv thiab kho mob me / nruab nrab tus kab mob COVID-19 (NOCOVID) Kev txhawb nqa los ntawm SaNOtize, qhov kev sim tshuaj thib 2 no tau ua hauv Canada thiab ua tiav. Txoj kev tshawb no tau sim ua tau zoo ntawm nws cov tswv cuab NORS (Nitric Oxide Releasing Solution) tsim los tiv thaiv thiab kho cov kab mob me me / nruab nrab^4,5.  

Raws li kev tshaj tawm los ntawm SaNOtize, kev tso tawm cov tshuaj NORS txo cov kab mob kis los ntawm ntau dua 95% hauv cov neeg koom nrog hauv 24 teev ntawm kev kho mob, thiab ntau dua 99% hauv 72 teev. Kev kho mob nrawm nrawm ntawm SARS-CoV-2 los ntawm qhov ua tau zoo ntawm 16-fold piv rau cov placebo uas tau txhawb nqa tiag tiag. Lub tuam txhab tab tom npaj Daim Ntawv Tso Cai Siv Thaum Muaj Xwm Ceev hauv UK thiab Canada tam sim ntawd⁶.  

Cia siab tias rov ua dua ntawm Nitric Oxide (NO) ua pov thawj pab tiv thaiv thiab kho Covid-19 mob sai sai.  

***

References: 

1. Gianni S., Fakhr BS., et al 2020. Nitric oxide gas inhalation los tiv thaiv COVID-2019 hauv cov kws kho mob. Ua ntej. MedRxiv. Tshaj tawm Lub Plaub Hlis 11, 2020. DOI: https://doi.org/10.1101/2020.04.05.20054544 

2. Pieretti JC., Rubilar O., et al 2021. Nitric oxide (NO) thiab nanoparticles – Tej zaum cov cuab yeej me me rau kev ua tsov rog tiv thaiv COVID-19 thiab lwm yam kab mob tib neeg tus kab mob. Kev tshawb nrhiav kab mob. Volume 291, 2 Lub Ib Hlis 2021, 198202. DOI: https://doi.org/10.1016/j.virusres.2020.198202 

3. Fang W., Jiang J., thiab al 2021. Lub luag haujlwm ntawm NO hauv COVID-19 thiab cov tswv yim kho muaj peev xwm. Dawb radical biology thiab tshuaj. Nqe 163, Nplooj 153-162. Luam tawm Lub Ob Hlis 1, 2021. DOI:https://doi.org/10.1016/j.freeradbiomed.2020.12.008 

4. Teb Chaws Asmeskas NLM 2021. Nitric Oxide tso cov kev daws teeb meem los tiv thaiv thiab kho tus kab mob me me / nruab nrab ntawm COVID-19 (NOCOVID). ClinicalTrials.gov Identifier: NCT04337918. Muaj nyob online ntawm https://www.clinicaltrials.gov/ct2/show/NCT04337918?term=SaNOtize+nasal+spray&cond=Covid19&draw=2&rank=2 Tau txais los ntawm 08 Lub Plaub Hlis 2021.  

5. SaNOtize, 2021. NORSTM – peb lub platform technology. Muaj nyob online ntawm https://sanotize.com Tau txais los ntawm 08 Plaub Hlis 2021.  

6. SaNOtize, 2021. Xov xwm tawm – UK Kev sim tshuaj xyuas tau lees paub SaNOtize txoj kev kho mob rau COVID19. Muaj nyob online ntawm https://www.businesswire.com/news/home/20210315005197/en/UK-Clinical-Trial-Confirms-SaNOtize’s-Breakthrough-Treatment-for-COVID-19 Tau txais los ntawm 08 Plaub Hlis 2021.  

***