NeoCoV, a mob hlwb Cov kab mob ntsig txog MERS-CoV pom hauv bats (NeoCoV tsis yog qhov hloov tshiab ntawm SARS-CoV-2, tib neeg mob hlwb Tus kab mob lub luag haujlwm rau COVID-19 kis thoob qhov txhia chaw) tau tshaj tawm tias yog thawj kis ntawm MERS-CoV variant siv ACE2. NeoCoV muaj peev xwm ntawm tib neeg tshwm sim nrog ob qho tib si neeg tuag taus thiab kis tus kab mob.
NeoCoV is a related strain to MERS-CoV that use bat UAS 2 receptors rau nws nkag thiab kis mus rau hauv bat cells. Txawm li cas los xij, cov kab mob ntawm MERS-CoV siv DPP4 receptors rau cellular nkag. Nws yog ib qho tseem ceeb kom nco ntsoov tias NeoCoV tsis yog qhov hloov pauv tshiab ntawm SARS-Cov-2 uas tau ua rau muaj kev sib kis thoob ntiaj teb txij li nws tshwm sim thaum lub Kaum Ib Hlis 2019.
Kab lus no qhia tau hais tias NeoCoV thiab nws cov txheeb ze ze PDF-2180-CoV muaj peev xwm ua tau zoo khi rau ACE 2 receptors hauv bat, tab sis khi tsis zoo rau tib neeg ACE 2 receptors. Kev tshawb fawb siv cryo-electron microscopy qhia qhov txawv tus kab mob no-ACE 2 binding surface in case of binding of NeoCoV and PDF-2180-CoV to ACE 2 receptors. Lub molecular determinant implicates Asp 338 residue, uas tiv thaiv NeoCoV los ntawm kev khi rau tib neeg ACE 2 receptor. Tsis tas li ntawd, T510F kev hloov pauv hauv cov receptor khi motif ntawm NeoCoV ua rau nws ua tau zoo khi tib neeg ACE 2 receptor.
Muab qhov kev tuag siab ntawm 35% cuam tshuam nrog MERS-CoV ntsig txog kab mob derived los ntawm Beta CoV kab mob, NeoCoV tuaj yeem ua rau muaj kev hem thawj rau kev tshwm sim ntawm cov kab mob sib kis tau zoo ntawm NeoCoV thiab PDF-2180-CoV (thaum tau txais T510F kev hloov pauv vim muaj cov kab mob antigenic drift) uas tuaj yeem ua rau kis kab mob thiab kev tuag ntawm tib neeg, ntau dua. tshaj qhov kev sib kis tam sim no. Antigenic drift yog hais txog random genetic change uas ua rau muaj kev hloov pauv hauv protein qauv, yog li hloov cov protein lub peev xwm los khi rau ib qho receptor tshwj xeeb. Tsis tas li ntawd, tus kab mob tshwm sim los ntawm T510F mutation ntawm NeoCoV, tsis tuaj yeem hla-neutralized los ntawm cov tshuaj tiv thaiv uas tsom rau SARS-CoV-2 lossis MERS-CoV.
Tag nrho cov zej zog thoob ntiaj teb cia siab tias qhov kev hloov pauv hauv NeoCoV thiab PDF-2180-CoV uas ua rau nws muaj txiaj ntsig zoo khi rau tib neeg ACE 2 receptor, tseem yog ib qho kev tshawb fawb hauv chav kuaj kom nkag siab txog kev ua phem ntawm cov no. kab mob, thiab nws tsis dhau los ua ib rooj plaub ntawm zoonotic kis tau los ntawm cov puav mus rau tib neeg, tsim kom muaj kev kub ntxhov thoob ntiaj teb.
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Tau qhov twg los:
Yan H., thiab al 2022. Cov txheeb ze ze ntawm MERS-CoV nyob rau hauv puav siv ACE2 ua lawv cov receptors ua haujlwm. Preprint bioRxiv. Tshaj tawm Lub Ib Hlis 25, 2022. DOI: https://doi.org/10.1101/2022.01.24.477490
 has been reported to be the first case of a MERS-CoV variant using ACE2. NeoCoV has potential of human emergence with both high fatality and transmission rate.){kind=link}