Cov biologics uas muaj xws li Canakinumab (monoclonal antibody), Anakinra (monoclonal antibody) thiab Rilonacept (fusion protein) tuaj yeem siv los ua kev kho mob uas txwv qhov mob ntawm cov neeg mob COVID-19. Tsis tas li ntawd, tus tsim qauv monoclonal antibodies tuaj yeem muab kev tiv thaiv kab mob tsis zoo los ntawm kev ua kom tus kab mob SARS-CoV-2 tiv thaiv kab mob.
Drug Discovery tab tom hloov nws cov chav kawm los ntawm cov tshuaj me me mus rau biologics uas muaj proteins thiab monoclonal tshuaj tiv thaiv raws li kev kho mob. Qhov no yog vim qhov tseeb dua ua rau muaj kev ua tau zoo dua ntawm protein-raws li tshuaj thiab txo cov kev mob tshwm sim thaum piv rau cov khoom me me. antibody-raws li kev kho mob uas txwv qhov mob yog ib qho ntawm cov tsev neeg tshuaj biologic loj tshaj plaws hauv biotech/pharmaceutical sectors.
Kev kis thoob qhov txhia chaw tsis ntev los no ntawm Covid-19 ua rau nws muaj feem ntau los txheeb xyuas thiab sau cov kev kho mob uas siv cov tshuaj uas twb muaj lawm1 los tiv thaiv tus kab mob COVID-19. Ib qho ntawm lawv yog kev siv cov tshuaj muaj monoclonal antibodies uas tuaj yeem siv tawm tsam cov NLRP3 inflammasome, ib lub hom phiaj tshuaj tshiab tau hais hauv kuv tsab xov xwm hnub tim 9th Lub Tsib Hlis 2020. Kab lus no tau piav qhia qhov tseem ceeb ntawm NLRP3 inflammasome uas yog lub hom phiaj tshuaj tshiab rau kev kho tus kab mob COVID-192. Hauv cov ntsiab lus no, kev siv cov tshuaj tiv thaiv kab mob monoclonal tiv thaiv IL-1 (interleukin-1)-beta thiab interleukin-18 (IL-18), uas yog cov cim ntawm kev ua kom mob plab.3, tuaj yeem ua pov thawj zoo tiv thaiv COVID-19 los ntawm kev txo qis qhov mob thiab yog li pab cov neeg mob.
Tam sim no muaj Canakinumab, tib neeg monoclonal tshuaj tiv thaiv tsom ntawm IL-1 beta muag raws li lub npe Ilaris4, yog ib qho tshuaj rau kev kho mob ntawm cov menyuam yaus idiopathic mob caj dab thiab cov kab mob tseem ceeb. Qhov no tuaj yeem sim thiab sim hauv cov neeg mob COVID-19 kom txo tau qhov mob thiab kis kab mob. Tsis tas li ntawd, Anakinra, ua lag luam raws li Kineret®, yog recombinant IL-1 receptor antagonist (IL-1ra) uas tuaj yeem siv los thaiv cov receptor thiab tiv thaiv kev ua ntawm IL-1 beta. Lwm biologic muaj yog Rilonacept (Arcalyst®)4, ib tug dimeric fusion protein muaj cov ligand-binding domain ntawm tib neeg IL-1 receptor thiab IL-1 receptor accessory protein uas tuaj yeem sim tiv thaiv IL-1 beta ua kom.
Ntxiv rau kev tsom mus rau cov txiaj ntsig qis ntawm COVID-19, xws li NLRP3 tau hais los saum no, kev txhim kho cov tshuaj tiv thaiv kab mob monoclonal uas tuaj yeem cuam tshuam tus kab mob thiab muab kev tiv thaiv tsis zoo rau cov pej xeem, kuj yog ib qho kev xav zoo nkauj txog thaum tsim tshuaj tiv thaiv.5,6,7.
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References:
- Soni, R., 2020. A Novel Approach to 'Repurpose' Existing Drugs For COVID-19. Kev tshawb fawb European. Published on May 7, 2020. Muaj nyob online ntawm https://www.scientificeuropean.co.uk/covid-19/a-novel-approach-to-repurpose-existing-drugs-for-covid-19/
- Soni, R., 2020. NLRP3 Inflammasome: Lub Hom Phiaj Tshuaj Kho Mob Zoo Tshaj Plaws rau Kev Kho Mob hnyav rau cov neeg mob COVID-19. Kev tshawb fawb European. Published on May 09, 2020. Muaj nyob online ntawm https://www.scientificeuropean.co.uk/covid-19/nlrp3-inflammasome-a-novel-drug-target-for-treating-severely-ill-covid-19-patients/
- Dolinay T, Kim YS, et al 2012. Inflammasome-regulated cytokines yog cov kws kho mob tseem ceeb ntawm kev mob ntsws ntsws. Am J Respir Crit Care Med, 185 (11) (2012), pp. 1225-1234. DOI: https://doi.org/10.1164/rccm.201201-0003OC
- Angeline XH Goh, Sebastien Bertin-Maghit, Siok Ping Yeo, Adrian Ho, Heidi Derks, Alessandra Mortellaro & Cheng-I Wang (2014) Ib tug tshiab tib neeg anti-interleukin-1β neutralizing monoclonal antibody uas qhia nyob rau hauv vivo efficacy, mAbs, 6:3 , 764-772, DOI: https://doi.org/ ib.10.4161/mab.28614
- Cohen, J. Designer antibodies tuaj yeem tiv thaiv COVID-19 ua ntej cov tshuaj tiv thaiv tuaj txog. DOI: https://doi.org/10.1126/science.abe1740
- Ledford, H. 2020. Cov tshuaj tiv thaiv kab mob tuaj yeem yog tus choj rau cov tshuaj tiv thaiv kab mob coronavirus - tab sis lub ntiaj teb puas tau txais txiaj ntsig? Xwm. Tshaj tawm rau 11th Lub Yim Hli 2020. DOI: https://doi.org/10.1038/d41586-020-02360-y
- NIH.gov 2020. NIH nthuav tawm kev sim tshuaj ntsuam xyuas tshuaj tiv thaiv kab mob hauv tsev kho mob cov neeg mob COVID-19. Published on August 4, 2020. Muaj nyob online ntawm https://www.nih.gov/news-events/news-releases/nih-launches-clinical-trial-test-antibody-treatment-hospitalized-covid-19-patients
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