Kev Kho Hniav: Povidone Iodine (PVP-I) Tiv Thaiv thiab Kho Thaum Ntxov ntawm COVID-19

Povidone Iodine (PVP-I) tuaj yeem siv rau hauv daim ntawv ntawm cov tshuaj ntxuav qhov ncauj thiab qhov ntswg (tshwj xeeb tshaj yog hauv Kev Kho Hniav thiab ENT chaw) txhawm rau tiv thaiv kev kis tus kab mob. SARS-Cov-2 tus kab mob, kom txo tau tus kab mob sib kis thiab tswj cov neeg mob thaum ntxov ntawm tus kab mob.  

Povidone iodine, feem ntau hu ua Betadine yog siv dav hauv tshuaj thiab kev kho hniav raws li ib tug zoo tshuaj pleev ib ce antiseptic rau ntau tshaj ib puas xyoo. Nws yog cov tshuaj tua kab mob dav tshaj plaws thiab muaj txiaj ntsig zoo tiv thaiv ntau yam kab mob xws li kab mob (gram-positive thiab gram negative), spores ntawm cov kab mob, protozoa, fungi thiab ntau yam kab mob, suav nrog H1N1 tus kab mob khaub thuas. ¹.  

Duo rau qhov xwm txheej txawv tshaj plaw nthuav tawm los ntawm Covid-19, ntau yam ntawm cov tswv yim tshuaj suav nrog kev rov ua cov tshuaj uas twb muaj lawm raug sim los tiv thaiv thiab kho tus kab mob no ⁷. Puas yog povidone iodine, uas paub tias muaj txiaj ntsig zoo tiv thaiv qee tus kab mob suav nrog SARS-CoV siv los ua tshuaj tua kab mob tiv thaiv kab mob SARS-CoV-2 thiab?  

Raws li tsab ntawv ceeb toom ua ntej ntawm kev ua tau zoo ntawm povidone iodine tiv thaiv tus kab mob SARS-CoV ², Challacombe et al tau npaj siv tshuaj tsuag qhov ntswg thiab qhov ncauj qhov ncauj / gargle ntawm povidone iodine los tswj kev kis tus kabmob tshiab los ntawm cov neeg mob kho hniav mus rau cov neeg ua haujlwm kho mob. ³. Tsis ntev, lwm cov kws tshawb fawb tau lees paub qhov ua tau zoo ntawm PVP-1 tiv thaiv tus kab mob SARS-CoV-2 hauv kev tshawb fawb hauv vitro. ^4,5 thiab tau hais kom siv PVP-I gargle thiab tshuaj ntxuav qhov ncauj hauv kev xyaum kho hniav ⁴ thiab ENT kev xyaum ⁶ kom txo qis kev pheej hmoo kis tus kab mob.  

Tam sim no, ntau qhov kev sim tshuaj tau ua tiav nyob rau ntau theem los ntsuas kev ua tau zoo ntawm povidone iodine hauv daim ntawv tshuaj ntxuav qhov ncauj thiab qhov ntswg hauv kev tiv thaiv thiab tswj kev tiv thaiv COVID-19. ⁷. Ob peb tau ua tiav, thiab lawv qhia tau zoo heev. Ib qho kev tshawb fawb ua ntej tshaj tawm 100% kev tshem tawm kab mob rau 1% povidone iodine hauv ib pab pawg me ntawm cov neeg mob uas tau lees paub theem 1 COVID-19. Cov kev tshawb fawb loj ntxiv yuav tsum tau lees paub qhov txiaj ntsig ntawm PVP-1 gargle rau cov neeg mob ntawm ntau theem ntawm COVID-19 ⁸. Hauv lwm qhov kev tshawb fawb tiav, kev siv 1% povidone iodine txo qis kev tuag thiab kev tuag ntawm cov neeg mob COVID-19. ⁹.  

Povidone iodine (PVP-1) qhov ncauj qhov ncauj thiab tshuaj tsuag qhov ntswg yog qhov yooj yim thiab muaj txiaj ntsig zoo rau kev txwv tsis pub kis thiab tswj cov theem pib. Covid-19 cov neeg mob.  

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References:  

1. Lachapelle, Castel, Casado et al.2013. Antiseptics nyob rau hauv lub era ntawm cov kab mob tsis kam: tsom rau povidone iodine. Clin. Xyaum. (2013) 10(5), 579–592. Muaj https://www.openaccessjournals.com/articles/antiseptics-in-the-era-of-bacterial-resistance-a-focus-on-povidone-iodine.pdf Tau txais los ntawm Lub Ib Hlis 27, 2021. 

2. Kariwa H, Fujii N, Takashima I. 2006. Inactivation of SARS coronavirus by means of povidone-iodine, cev nqaij daim tawv thiab tshuaj reagents. Dermatology 2006; 212 Ib.: 119-123. DOI: https://doi.org/10.1159/000089211  

3. Challacombe, S., Kirk-Bayley, J., Sunkaraneni, V. et al. Povidone iodine. Br Dent J 228, 656–657 (2020). Published 08 May 2020 DOI:https://doi.org/10.1038/s41415-020-1589-4 

4. Hassandarvish, P., Tiong, V., Sazaly, A. et al. Povidone iodine gargle thiab yaug qhov ncauj. Br Dent J 228, 900 (2020). Published: 26 June 2020. DOI: https://doi.org/10.1038/s41415-020-1794-1 

5. Zoltán K., 2020. In Vitro Efficacy of “Iodine Essential Drops” Against Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV-2). Preprint bioRxiv. Tshaj tawm rau lub Kaum Ib Hlis 10, 2020. DOI: https://doi.org/10.1101/2020.11.07.370726 

6. Khan MM, Parab SR thiab Paranjape M., 2020. Repurposing 0.5% povidone iodine tov nyob rau hauv otorhinolaryngology xyaum nyob rau hauv Covid 19 kis. American Journal of Otolaryngology, Volume 41, Issue 5, 2020, 102618, DOI: https://doi.org/10.1016/j.amjoto.2020.102618 

7. Scarabel L., et al., 2021. Pharmacological strategies to prevent SARS-CoV-2 infection and to treat the early phase of COVID-19 disease. International Journal of Infectious Diseases. Muaj nyob online 18 Lub Ib Hlis 2021. DOI: https://doi.org/10.1016/j.ijid.2021.01.035 

8. Mohamed NA., Baharom N., 2020. Early Viral Clearance Ntawm Covid-19 Cov Neeg Mob Thaum Gargling nrog Povidone-iodine Thiab Cov Roj Tseem Ceeb: Kev sim kuaj sim. Ua ntej. medRxiv. Tshaj tawm rau lub Cuaj Hlis 09, 2020. DOI: https://doi.org/10.1101/2020.09.07.20180448  

9. Choudhury MIM, Shabnam N., et al 2021. “Cov nyhuv ntawm 1% Povidone Iodine Mouthwash/Gargle, Nasal and Eye Drop in COVID-19 patient”, Bioresearch Communications-(BRC), 7(1), pp. 919-923 . Muaj nyob ntawm: http://www.bioresearchcommunications.com/index.php/brc/article/view/176  (Tau txais: 27 Lub Ib Hlis 2021). 

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