COVID-19, Kev tiv thaiv kab mob & zib ntab: Kev nce qib tsis ntev los no hauv kev nkag siab txog tshuaj kho mob ntawm Manuka zib ntab

Cov khoom tiv thaiv kab mob ntawm manuka zib ntab yog vim muaj cov tshuaj methylglyoxal (MG), arginine qhia glycating tus neeg sawv cev uas hloov kho cov chaw tshwj xeeb uas muaj nyob rau hauv SARS-CoV-2 genome, yog li cuam tshuam nrog nws cov replication thiab inhibiting tus kab mob. Tsis tas li ntawd, manuka zib ntab kuj pom muaj zog tiv thaiv kab mob thiab tiv thaiv qog noj ntshav. Txog tam sim no, manuka zib ntab tuaj yeem yog ambrosia uas yuav tau noj los txhawb kev tiv thaiv kab mob, suav nrog COVID-19. li no txhawb kev noj qab haus huv.

Hauv kev nyab xeeb tam sim no ntawm Covid-19 Tus kab mob kis thoob qhov txhia chaw tshwj xeeb tshaj yog thaum SARS-CoV-2 hloov pauv ntawm qhov nrawm zuj zus, ua rau muaj kev sib kis ntau ntxiv ua rau muaj kev txhawj xeeb, nws yuav muaj feem xyuam rau kev tshawb nrhiav thiab siv cov peev txheej uas yuav muaj peev xwm txhawb kev tiv thaiv thiab pab txhawb kev tawm tsam. Covid-19 kom txo tau kev mob thiab kev tuag, yog li txhim kho kev noj qab haus huv.  

Ntxiv rau kev noj ntawm Vitamin C thiab D los txhawb lub cev tiv thaiv kab mob, zib mu, tshwj xeeb tshaj yog Mānuka zib mu (ib monofloral zib mu ua los ntawm nectar ntawm tsob ntoo mānuka, Leptospermum scoparium  los ntawm European zib muv (apis mellifera) tau nkag siab tias yuav muab cov txiaj ntsig kev noj qab haus huv raws li kev tiv thaiv kab mob tiv thaiv kab mob. Kab lus no yuav tshuaj xyuas, tshuaj xyuas thiab tshuaj xyuas cov pov thawj los ntawm kev tshawb fawb tsis ntev los no hais txog manuka zib ntab thiab nws cov khoom siv tshuaj. Manuka zib mu yog tsim los ntawm paj ntawm manuka ntoo uas nws yog ib txwm nyob ntawm Australia thiab New Zealand. 

Qhov tseem ceeb ntawm manuka zib mu uas yog lub luag haujlwm rau nws cov kab mob tua kab mob thiab tiv thaiv kab mob yog qhov muaj ntau ntawm methylglyoxal (MG). Thaum MG muaj nyob rau hauv txhua hom zib mu ntawm ntau yam sib txawv, nws yog tam sim no nyob rau hauv ib tug heev concentration nyob rau hauv manuka zib mu. Siab dua MG tshwm sim los ntawm kev hloov pauv ntawm dihydroxyacetone uas muaj nyob rau hauv paj ntawm tsob ntoo manuka ntawm qhov siab siab. Siab dua MG, siab dua cov tshuaj tua kab mob. Manuka zib ntab yog ntsuas siv qhov ntsuas ntsuas hu ua UMF (Unique Manuka Factor). Siab dua UMG, siab dua cov tshuaj tua kab mob ntawm manuka zib ntab thiab ntau dua nws cov nqi. 

Nws tau raug pom tias MG, tam sim no nyob rau hauv cov ntsiab lus tseem ceeb hauv manuka zib ntab, tuaj yeem ua raws li arginine-directed glycating tus neeg sawv cev, rau kev xaiv toxicity rau SARS-Cov-2. Kev soj ntsuam ib ntus ntawm SARS-CoV-2 proteome tau nthuav tawm pom muaj 5-fold enrichment ntawm methylglyoxal hloov chaw nyob hauv SARS-CoV-2 proteome, piv rau tib neeg tus tswv - qhia txog kev xaiv tshuaj lom ntawm methylglyoxal rau tus kab mob. ⁽¹⁾. Manuka zib ntab tuaj yeem cuam tshuam nrog tus kab mob replication thiab inhibit qhov kev loj hlob ntawm cov kab mob hauv lub hnab ⁽²⁾. Anti-viral thiab immunomodulatory teebmeem ntawm manuka zib ntab kuj tuaj yeem raug sau tseg rau qhov muaj phenolic tebchaw uas ua raws li cov tshuaj tiv thaiv oxidants. ⁽³⁾. Lub xub ntiag ntawm phenolic tebchaw, flavonoids xws li quercetin tuaj yeem cuam tshuam 3-chymotrypsin-zoo li cysteine ​​protease, ib qho enzyme uas ua lub luag haujlwm tseem ceeb hauv kab mob lub neej. ⁽⁴⁾, yog li nthuav tawm tshuaj tiv thaiv kab mob teebmeem ntawm manuka zib mu. 

Cov khoom siv tshuaj tua kab mob ntawm manuka zib ntab los ntawm qhov muaj hydrogen peroxide, pH qis thiab cov ntsiab lus qab zib siab, cov yam ntxwv uas pom muaj nyob rau lwm hom zib ntab zoo li. Cov nyhuv antibacterial ntawm manuka zib ntab tau pom los ntawm kev txo qis MRSA cell viability hauv biofilm. ⁽⁵⁾. Qhov no yog vim qhov txo qis ntawm cov noob encoding laminin- (eno), elastin-(ua ebpsthiab fibrinogen binding protein (fib), Thiab icaA thiab icaD, koom nrog biosynthesis ntawm polysaccharide intercellular adhesin nyob rau hauv ob qho tib si tsis muaj zog thiab muaj zog adhering strain, piv rau kev tswj. Manuka zib ntab kuj tau nthuav tawm cov haujlwm tawm tsam Escherichia coli O157:H7 hauv biofilms ⁽⁶⁾ as Well as bactericidal thiab anti-spore tsim kev ua si tawm tsam Clostridioides nyuaj  ⁽⁷⁾. 

Tsis tas li ntawd, manuka zib ntab kuj tau pom tias muaj kev tiv thaiv kab mob qog noj ntshav. Qhov no tau tshwm sim los ntawm lub peev xwm ntawm manuka zib mu rau induce apoptosis nyob rau hauv cov kab mob qog noj ntshav los ntawm kev tswj cov permeability siab ntawm hydrogen peroxide tawm tsam intracellular reactive oxygen hom. ⁽⁸⁾ . Cov nyhuv antitumor ntawm manuka zib mu yog vim inhibitory cuam tshuam ntawm inflammatory thiab oxidative kev nyuaj siab signaling nrog rau inhibition ntawm proliferation thiab metastasis tivthaiv kev ua ub no. ⁽⁹⁾. 

Zoo li muaj pov thawj txaus los qhia tias noj zib mu, tshwj xeeb tshaj yog manuka zib mu yuav pab tib neeg txhim kho lawv txoj kev tiv thaiv kab mob vim muaj cov tshuaj tiv thaiv kab mob thiab cov kab mob los ntawm kev muaj MG. Tsis tas li ntawd, kev noj manuka zib ntab ua ib feem ntawm kev tswj hwm lub neej kuj tseem tuaj yeem pab tiv thaiv qog noj ntshav. Nws puas tsim nyog xav tias manuka zib ntab yog panacea rau txhua yam mob uas cuam tshuam rau noob neej? Lub sij hawm yuav qhia thiab cov lus teb yuav dag nyob rau hauv kev soj ntsuam ntawm cov ntaub ntawv generated los ntawm ntau cov kev tshawb fawb ntawm kev noj manuka zib mu. Txawm li cas los xij, rau tam sim no, manuka zib ntab zoo li yog ambrosia uas yuav tau noj rau nws cov khoom siv tshuaj los tiv thaiv qhov mob hnyav ntawm cov kab mob thiab kab mob xws li Covid-19. 

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References 

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