CD24: Tus Tshuaj Tiv Thaiv Kab Mob rau Kev Kho Mob ntawm COVID-19 Cov Neeg Mob

cov soj ntsuam ntawm ntawm Tel-Aviv Sourasky Medical Center tau ua tiav kev sim Phase I rau kev siv CD24 protein xa hauv exosomes los kho Covid-19.

Cov kws tshawb fawb ntawm Tel-Aviv Sourasky Medical Center tau tsim ib tus kws kho mob bio-kho raws li exosomes (membrane bound vesicles) nqa CD24. protein. Cov exosomes no ua lub tsheb xa khoom rau CD24 protein. Cov exosomes uas muaj CD24 tau raug cais tawm thiab ua kom huv huv los ntawm T-REx™-293 hlwb uas tau tsim cov noob caj noob ces kom dhau-express CD24. Tsis tas li ntawd, cov kws tshawb fawb ntawm OncoImmune Inc. tau qhia txog kev siv CD24Fc (fusion protein ntawm CD24 nrog Fc) raws li kev kho mob. Covid-19 hauv kev sim tshuaj. 

CD24 yog cov cim protein ntau uas tau pom tias muaj ntau dhau ntawm tib neeg Cancer¹ thiab kev yos hav zoov yog nyob rau tshwj xeeb anti-CD24 cov tshuaj tiv thaiv los tiv thaiv qog noj ntshav. Txawm li cas los xij, ironically, nyob rau hauv rooj plaub ntawm COVID-19, cov kws tshawb fawb tau sim tswj hwm CD24 cov protein kom tiv thaiv kev mob tshwm sim los ntawm cytokine cua daj cua dub thiab yog li tiv thaiv tus kab mob COVID-19. Qhov laj thawj tom qab siv CD24 tiv thaiv kab mob COVID-19 hauv cov neeg mob cuam tshuam nrog cov kab mob nruab nrab mus rau qhov hnyav yog tias CD24 tau cuam tshuam rau kev tswj hwm lub cev tsis zoo hauv acetaminophen ua rau lub siab raug mob.², qhov twg hauv nas tsis muaj CD24 protein tuag thaum cov nas ib txwm nrog CD24 protein qhia tau muaj sia nyob. Tsis tas li ntawd, kev kho mob nrog CD24Fc (CD24 fused nrog Fc protein) tsis tsuas yog txo cov kev qhia ntawm IL-6 thiab lwm yam inflammatory cytokines hauv Suav rhesus macaques (ChRMs) nrog Simian Immune deficiency Virus.³, tab sis kuj tiv thaiv lawv tiv thaiv kab mob ntsws⁴.  

Qhov no tau ua rau cov kws tshawb fawb siv CD24 protein los tiv thaiv kev mob los ntawm tus kab mob COVID-19. Thaum cov kws tshawb fawb ntawm OncoImmune Inc. tau siv CD24Fc (xa raws li IV infusion hauv ib txwm saline) nyob rau hauv ib qho randomized, ob-dig muag, placebo-tswj, ntau qhov chaw, Phase III kawm.⁵ txhawm rau ntsuas nws txoj kev nyab xeeb thiab kev ua tau zoo tiv thaiv COVID-19, cov kws tshawb fawb ntawm Tel-Aviv Sourasky Medical Center tau ua tiav kev sim Phase I.⁶ rau kev siv CD24 protein xa hauv exosomes los kho COVID-19. EXO-CD24 tau muab rau 35 tus neeg mob raws li aerosolized nyob rau hauv ib txwm saline rau inhalation. Tag nrho 30 tus neeg mob tau zoo thiab 29 ntawm lawv zoo li 3-5 hnub. Cov txiaj ntsig txhawb nqa no tau lees paub ntxiv rau Theem II thiab theem III kev sim siab ntxiv kom ntseeg tau tias nws muaj kev nyab xeeb thiab ua tau zoo thiab tso cai rau nws tau txais kev pom zoo los ntawm cov neeg tswj hwm siv rau cov neeg mob COVID-19. 

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References 

1. Shapira, S., Finkelshtein, E., Kazanov, D. et al. Integrase-derived peptides ua ke nrog CD24-targeted lentiviral particles inhibit qhov kev loj hlob ntawm CD24 qhia cov qog nqaij hlav cancer. Oncogene (2021). https://doi.org/10.1038/s41388-021-01779-5 

2. Chen GY, Tang J, Zheng P, Liu Y. CD24 thiab Siglec-10 xaiv xaiv cov ntaub so ntswg puas-induced lub cev tiv thaiv kab mob. Kev tshawb fawb. 2009 Peb Hlis 27; 323(5922): 1722-5. DOI: https://doi.org/ 10.1126/science.1168988. Epub 2009 Mar 5. 

3. Tian RR, Zhang MX, Zhang LT, Zhang P, Ma JP, Liu M, Devenport M, Zheng P, Zhang XL, Lian XD, Ye M, Zheng HY, Pang W, Zhang GH, Zhang LG, Liu Y, Zheng YT . CD24 thiab Fc fusion protein tiv thaiv SIVmac239-infected Suav rhesus macaque tiv thaiv kev loj hlob mus rau AIDS. Antiviral Res. 2018 Sep; 157:9-17. DOI: https://doi.org/10.1016/j.antiviral.2018.07.004. Epub 2018 Jul 3. 

4. Tian RR, Zhang MX, Liu M, Fang X, Li D, Zhang L, Zheng P, Zheng YT, Liu Y. CD24Fc tiv thaiv kab mob ntsws hauv simian immunodeficiency virus-infected Suav rhesus liab. Cell Mol Immunol. 2020 Aug; 17(8):887-888. DOI: https://doi.org/ 10.1038/s41423-020-0452-5. Epub 2020 May 7. 

5. CD24Fc ua ib qho tshuaj tiv thaiv kab mob tsis muaj tshuaj tiv thaiv kab mob hauv kev kho COVID-19 (SAC-COVID). Muaj nyob online ntawm https://clinicaltrials.gov/ct2/show/NCT04317040 

6. Kev ntsuas kev nyab xeeb ntawm CD24-Exosomes hauv cov neeg mob uas muaj tus kab mob COVID-19. Muaj nyob online ntawm https://clinicaltrials.gov/ct2/show/NCT04747574 

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