Interferon-β rau kev kho mob ntawm COVID-19: Kev tswj hwm subcutaneous zoo dua

Cov txiaj ntsig tau los ntawm kev sim theem 2 txhawb kev pom tias kev tswj hwm subcutaneous ntawm IFN- β rau kev kho mob ntawm COVID-19 txhim kho kev rov qab sai thiab txo cov neeg tuag..

Qhov xwm txheej tshwj xeeb uas tau nthuav tawm los ntawm COVID-19 kis thoob qhov txhia chaw tau lees paub tshawb nrhiav ntau txoj hauv kev rau kev kho mob ntawm COVID-19 mob hnyav. Ob peb cov tshuaj tshiab raug sim thiab cov tshuaj uas twb muaj lawm tau rov ua dua. Corticosteroids twb pom tias muaj txiaj ntsig. Kev kho Interferon twb tau siv rau kev kis kab mob xws li kab mob siab. IFN puas tuaj yeem siv tawm tsam SARS CoV-2 hauv COVID-19?  

Hauv kev sim ua ntej ua ntej, IFN tau ua pov thawj tias muaj txiaj ntsig tiv thaiv SARS CoV thiab MERS kab mob. Thaum Lub Xya Hli 2020, kev tswj hwm ntawm Interferon-β los ntawm nebulisation (viz. pulmonary inhalation) txoj hauv kev tau tshaj tawm los qhia cov txiaj ntsig tau zoo hauv kev kho mob COVID-19 mob hnyav raws li cov ntaub ntawv los ntawm theem 2 kev sim tshuaj. ^1,2.  

Tam sim no, tsab ntawv tshaj tawm tshiab tshaj plaws raws li cov ntaub ntawv los ntawm theem 2 kev sim tshuaj ntsuam xyuas tau ua rau 112 tus neeg mob nrog COVID-19 nyob hauv tsev kho mob ntawm Pitié-Salpêtrière hauv Paris, Fabkis qhia tias kev tswj hwm ntawm IFN- β los ntawm txoj kev subcutaneous txhim kho tus nqi rov qab thiab txo cov neeg tuag hauv COVID-19. rooj plaub ³.   

Interferons (IFN) yog cov protein uas zais cia los ntawm cov tswv tsev hauv cov teb rau cov kab mob kis mus rau lwm lub hlwb kom pom muaj tus kab mob. Cov lus teb tsis txaus ntseeg nyob hauv qee tus neeg mob COVID-19 tau pom tias muaj feem cuam tshuam nrog IFN-1 cov lus teb tsis zoo thiab thaiv IFN-IB zais cia. Nws yog siv nyob rau hauv Tuam Tshoj los kho tus kab mob pneumonia vim SARS CoV tab sis nws siv tsis yog qauv ⁴.  

Theem 3 kev sim tshuaj rau kev siv Interferons (IFN) hauv kev kho mob rau cov neeg mob COVID-19 hnyav tam sim no tab tom ua tiav. Kev pom zoo yuav nyob ntawm seb cov txiaj ntsig kawg puas nyob hauv qhov kev lees paub tau teev tseg los ntawm cov tswj hwm.   

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Qhov chaw:   

1. NHS 2020. Xov Xwm- Cov tshuaj nqus tau pa tiv thaiv COVID-19 cov neeg mob hnyav dua hauv Southampton sim. Tshaj tawm rau Lub Xya Hli 20, 2020. Muaj nyob online ntawm https://www.uhs.nhs.uk/ClinicalResearchinSouthampton/Research/News-and-updates/Articles/Inhaled-drug-prevents-COVID-19-patients-getting-worse-in-Southampton-trial.aspx Tau txais los ntawm 12 Lub Ob Hlis 2021.  

2. Monk PD., Marsden RJ., Tear VJ., et al., 2020. Kev nyab xeeb thiab kev ua tau zoo ntawm kev nqus pa nebulised interferon beta-1a (SNG001) rau kev kho tus kab mob SARS-CoV-2: randomised, ob-dig muag, placebo- tswj, theem 2 mus sib hais. Lancet Respiratory Medicine, Muaj nyob online 12 Kaum Ib Hlis 2020. DOI: https://doi.org/10.1016/S2213-2600(20)30511-7 

3. Dogham K., Neumann AU., et al 2021. Xav txog kev kho tus kheej Interferon-β rau COVID-19. Antimicrobial Agents Chemotherapy. Tshaj tawm Online 8 Lub Ob Hlis 2021. DOI: https://doi.org/10.1128/AAC.00065-21  

4. Mary A., Hénaut L., Macq PY., et al 2020. Rationale for COVID-19 Treatment by Nebulized Interferon-β-1b–Literature Review and Personal Preliminary Experience. Frontiers in Pharmacology., 30 Kaum Ib Hlis 2020. DOI:https://doi.org/10.3389/fphar.2020.592543.  

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